Nishimaki T, Hölscher A H, Schüler M, Becker K, Muto T, Siewert J R
First Department of Surgery, Niigata University School of Medicine, Japan.
Surg Today. 1994;24(3):203-9. doi: 10.1007/BF02032888.
Chronic esophagitis and the subsequent morphological changes of the esophageal mucosa were histologically studied in esophagectomy specimens from 15 patients with Barrett's esophagus. Basal layer hyperplasia with papillary elongation, intraepithelial eosinophils, and intraepithelial neutrophils were found in the squamous epithelium of all (100%), 7 (46.7%), and 14 (93.3%) of the 15 specimens, respectively. Moreover, a specialized type of Barrett's mucosa was found in the metaplastic columnar lining of all the specimens. The muscularis mucosae appeared intact beneath the squamous epithelium lining the proximal esophagus in 13 specimens (86.7%), while it became thick and "dual" beneath the metaplastic columnar epithelium lining the distal esophagus in 14 specimens (93.3%). This dual muscularis mucosae, as well as the metaplastic columnar epithelium, particularly the specialized type, may be part of the specific histological changes characteristic of Barrett's esophagus.
对15例巴雷特食管患者的食管切除标本进行组织学研究，观察慢性食管炎及随后食管黏膜的形态学变化。在15个标本的鳞状上皮中，分别有100%（15/15）、46.7%（7/15）和93.3%（14/15）出现了基底细胞增生伴乳头延长、上皮内嗜酸性粒细胞和上皮内中性粒细胞。此外，在所有标本的化生柱状上皮中均发现了一种特殊类型的巴雷特黏膜。在13个标本（86.7%）中，食管近端鳞状上皮下的黏膜肌层完整，而在14个标本（93.3%）中，食管远端化生柱状上皮下的黏膜肌层变厚且呈“双层”。这种双层黏膜肌层以及化生柱状上皮，尤其是特殊类型，可能是巴雷特食管特征性组织学变化的一部分。
