Gürgan T, Diker K S, Haziroglu R, Urman B, Akan M
Department of Obstetrics and Gynecology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Gynecol Obstet Invest. 1994;37(3):164-7. doi: 10.1159/000292549.
To assess whether Candida species can penetrate intact fetal membranes under in vitro conditions, Candida albicans, Candida tropicalis, Candida guilliermondii, Candida pseudotropicalis and Candida glabrata were inoculated onto the surface of the maternal side of the membranes obtained from 4 pregnant women undergoing repeat cesarean section. After incubation under culture conditions, membranes were evaluated by histological examination. C. albicans inoculated onto the maternal side penetrated and passed to the fetal side and caused some degeneration of the structure of the membrane epithelium. The other four Candida species grew heavily on the maternal surface but did not penetrate and invade the membranes. This effect of C. albicans on fetal membranes may explain the potential mechanism in the development of Candida infections of the amniotic fluid, fetal membranes and possibly the fetus.
为评估念珠菌属在体外条件下能否穿透完整的胎膜，将白色念珠菌、热带念珠菌、季也蒙念珠菌、伪热带念珠菌和光滑念珠菌接种到4例接受再次剖宫产的孕妇所获得的胎膜母体侧表面。在培养条件下孵育后，通过组织学检查评估胎膜。接种在母体侧的白色念珠菌穿透并转移至胎儿侧，导致膜上皮结构出现一些变性。其他四种念珠菌在母体表面大量生长，但未穿透和侵袭胎膜。白色念珠菌对胎膜的这种作用可能解释了羊水、胎膜乃至胎儿念珠菌感染发生发展的潜在机制。
