Koleri Junais, Hamad Hani Ghassan, Ben Abid Fatma, Sasi Sreethish, Ittaman Ajithkumar V, AlMaslamani Muna
Department of Infectious Diseases, Communicable Diseases Centre, Hamad Medical Corporation, Qatar.
IDCases. 2025 Jul 17;41:e02325. doi: 10.1016/j.idcr.2025.e02325. eCollection 2025.
Fungal chorioamnionitis is a rare but potentially life-threatening complication of pregnancy with significant maternal and fetal consequences. We describe a severe case of chorioamnionitis in a 19-week twin pregnancy conceived through in vitro fertilization (IVF), resulting in maternal septic shock and fetal demise. The patient was successfully treated with anidulafungin after the identification of in blood and placental cultures. This case highlights the growing association between assisted reproductive technologies and fungal chorioamnionitis, emphasizing the need for increased awareness, early diagnosis, and appropriate management of this condition. The literature review suggests a significant relationship between IVF procedures and infections, with implications for pre-procedural screening and prophylaxis in high-risk patients.
真菌性绒毛膜羊膜炎是一种罕见但可能危及生命的妊娠并发症，会对母婴产生严重后果。我们报告一例通过体外受精（IVF）受孕的19周双胎妊娠并发严重绒毛膜羊膜炎的病例，该病例导致产妇感染性休克和胎儿死亡。在血液和胎盘培养物中鉴定出相关病菌后，患者接受了阿尼芬净治疗并成功康复。该病例凸显了辅助生殖技术与真菌性绒毛膜羊膜炎之间日益紧密的联系，强调了提高对此病的认识、早期诊断及适当管理的必要性。文献综述表明IVF程序与感染之间存在显著关联，这对高危患者的术前筛查和预防具有重要意义。
