一种编码分化抗原的新基因，该抗原可被HLA - A2黑色素瘤上的自体细胞溶解T淋巴细胞识别。
A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.
作者信息
Coulie P G, Brichard V, Van Pel A, Wölfel T, Schneider J, Traversari C, Mattei S, De Plaen E, Lurquin C, Szikora J P, Renauld J C, Boon T
机构信息
Ludwig Institute for Cancer Research, Brussels, Belgium.
出版信息
J Exp Med. 1994 Jul 1;180(1):35-42. doi: 10.1084/jem.180.1.35.
Abstract
It has been reported previously that antitumor cytolytic T lymphocyte (CTL) clones can be isolated from blood lymphocytes of HLA-A2 melanoma patients, after stimulation in vitro with autologous tumor cells, and that some of these CTL clones lyse most HLA-A2 melanomas. A first antigen recognized by such CTL clones was previously shown to be encoded by the tyrosinase gene. We report here the identification of another gene that also directs the expression of an antigen recognized on most melanomas by CTL clones that are restricted by HLA-A2. The gene, designated Melan-A, is unrelated to any known gene. It is 18 kb long and comprises five exons. Like the tyrosinase gene, it is expressed in most melanoma tumor samples and, among normal cells, only in melanocytes.
摘要
先前已有报道称，在体外经自体肿瘤细胞刺激后，可从HLA - A2黑色素瘤患者的血液淋巴细胞中分离出抗肿瘤细胞溶解性T淋巴细胞（CTL）克隆，并且其中一些CTL克隆可裂解大多数HLA - A2黑色素瘤。先前已表明，此类CTL克隆识别的第一种抗原由酪氨酸酶基因编码。我们在此报告另一个基因的鉴定结果，该基因也指导一种抗原的表达，这种抗原在大多数黑色素瘤上可被受HLA - A2限制的CTL克隆识别。该基因命名为Melan - A，与任何已知基因均无关联。它长18 kb，由五个外显子组成。与酪氨酸酶基因一样，它在大多数黑色素瘤肿瘤样本中表达，而在正常细胞中，仅在黑素细胞中表达。
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本文引用的文献
1
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J Exp Med. 1993 Apr 1;177(4):989-98. doi: 10.1084/jem.177.4.989.
2
Recognition of shared melanoma antigen by HLA-A2-restricted cytolytic T cell clones derived from human tumor-infiltrating lymphocytes.源自人肿瘤浸润淋巴细胞的HLA-A2限制性细胞毒性T细胞克隆对共享黑色素瘤抗原的识别。
Eur J Immunol. 1993 Jan;23(1):141-6. doi: 10.1002/eji.1830230123.
3
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J Exp Med. 1993 Aug 1;178(2):489-95. doi: 10.1084/jem.178.2.489.
4
Genes coding for tumor antigens recognized by human cytolytic T lymphocytes.编码可被人细胞溶解T淋巴细胞识别的肿瘤抗原的基因。
J Immunother Emphasis Tumor Immunol. 1993 Aug;14(2):104-9. doi: 10.1097/00002371-199308000-00004.
5
Expression of mage genes by non-small-cell lung carcinomas.非小细胞肺癌中mage基因的表达。
Int J Cancer. 1994 Mar 15;56(6):826-9. doi: 10.1002/ijc.2910560612.
6
Melanocyte lineage-specific antigen gp100 is recognized by melanoma-derived tumor-infiltrating lymphocytes.黑色素细胞谱系特异性抗原gp100可被黑色素瘤来源的肿瘤浸润淋巴细胞识别。
J Exp Med. 1994 Mar 1;179(3):1005-9. doi: 10.1084/jem.179.3.1005.
7
Analysis of antigens recognized on human melanoma cells by A2-restricted cytolytic T lymphocytes (CTL).A2 限制性细胞毒性 T 淋巴细胞（CTL）对人黑色素瘤细胞上识别抗原的分析。
Int J Cancer. 1993 Sep 9;55(2):237-44. doi: 10.1002/ijc.2910550212.
8
T-cell-mediated cytotoxicity against autologous malignant melanoma: analysis with interleukin 2-dependent T-cell cultures.针对自体恶性黑色素瘤的T细胞介导的细胞毒性：白细胞介素2依赖性T细胞培养分析
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9
Clonal analysis of cytotoxic T cell response against human melanoma.针对人类黑色素瘤的细胞毒性T细胞反应的克隆分析。
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