Compston A
University of Cambridge Neurology Unit, Addenbrooke's Hospital.
J R Coll Physicians Lond. 1994 Mar-Apr;28(2):107-20.
Diseases of the human brain and spinal cord are common and often progressive since, unlike peripheral nerve, the adult human central nervous system does not spontaneously repair itself. Studies on development and cell lineages in the nervous system have started to elucidate the scientific basis for this lack of regeneration, and have suggested ways of enhancing repair. At the same time, improved understanding of neurodegenerative processes has provided a rationale for treatments which limit neuronal and glial damage. Cell implantation has been tested, experimentally and in man, and with some prospects for successful restoration of normal cell arrangements in the central nervous system. Taken together, a coherent strategy for limiting the damage and repairing the brain is beginning to emerge. The translation of these ideas into clinical practice is timely and eagerly awaited.
人类大脑和脊髓疾病很常见，而且往往会不断发展，因为与周围神经不同，成年人类中枢神经系统不会自发修复自身。对神经系统发育和细胞谱系的研究已开始阐明这种缺乏再生能力的科学依据，并提出了增强修复的方法。与此同时，对神经退行性过程的更深入了解为限制神经元和神经胶质损伤的治疗提供了理论依据。细胞植入已在实验和人体中进行了测试，并且在成功恢复中枢神经系统正常细胞排列方面有一些前景。综上所述，一种限制损伤和修复大脑的连贯策略开始显现。将这些想法转化为临床实践既及时又备受期待。
