Nagamitsu S
Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Kurume Med J. 1993;40(4):233-41. doi: 10.2739/kurumemedj.40.233.
To investigate pediatric brain impairment, beta-endorphin levels, one of the opioid peptides that modulate human high cortical functions, were measured in cerebrospinal fluid (CSF). The study included 19 patients with infantile autism, 3 patients with Rett syndrome, 6 patients with infantile spasms, 16 patients with aseptic meningitis, and 23 age-matched controls. In the control group, the CSF beta-endorphin concentrations were negatively correlated with increasing age. There was no correlation between body temperature and the levels, and no significant difference in the levels according to sex. In infantile autism, the CSF level was not significantly different from that in controls. In Rett syndrome, it was significantly higher, while in infantile spasms it was lower than in controls. In aseptic meningitis, the CSF beta-endorphin level was significantly higher than in controls. The alterations in CSF beta-endorphin levels may play a role in these neurologic disorders and/or in central nervous system (CNS) infections.
为研究小儿脑损伤情况，对脑脊液（CSF）中β-内啡肽水平进行了检测，β-内啡肽是调节人类高级皮质功能的阿片肽之一。该研究纳入了19例婴儿自闭症患者、3例雷特综合征患者、6例婴儿痉挛症患者、16例无菌性脑膜炎患者以及23例年龄匹配的对照组。在对照组中，脑脊液β-内啡肽浓度与年龄增长呈负相关。体温与该水平之间无相关性，且按性别划分该水平无显著差异。在婴儿自闭症中，脑脊液水平与对照组无显著差异。在雷特综合征中，该水平显著更高，而在婴儿痉挛症中则低于对照组。在无菌性脑膜炎中，脑脊液β-内啡肽水平显著高于对照组。脑脊液β-内啡肽水平的改变可能在这些神经系统疾病和/或中枢神经系统（CNS）感染中起作用。
