Satoi M
Department of Pediatrics and Child Health, Kurume University School of Medicine, Japan.
Kurume Med J. 1999;46(1):17-23. doi: 10.2739/kurumemedj.46.17.
To clarify the role of beta-phenylethylamine (PEA) in pediatric neurological disorders, we have measured the cerebrospinal fluid (CSF) levels of PEA in 12 children with aseptic meningitis--6 were in the acute phase and the other 6 were in the recovery phase--and 5 children with Rett Syndrome (RS). The findings were compared with those obtained from 13 age-matched children with leukemia as child controls and from 10 adults patients without any neurological symptoms and signs as control. In the control group, the CSF PEA level was negatively correlated with age until 200 months (17 years) old. The mean PEA levels in meningitis and RS were significantly lower than that of child controls (p < 0.03). The alteration in the CSF levels of PEA may be related to transient changes in the dopaminergic tone in aseptic meningitis and neurological impairment, especially in the dopaminergic neurons in RS.
为阐明β-苯乙胺（PEA）在小儿神经疾病中的作用，我们检测了12例无菌性脑膜炎患儿（6例处于急性期，6例处于恢复期）及5例雷特综合征（RS）患儿脑脊液（CSF）中PEA的水平。研究结果与13例年龄匹配的白血病患儿（作为儿童对照）及10例无任何神经症状和体征的成年患者（作为对照）的检测结果进行了比较。在对照组中，脑脊液PEA水平在200个月（17岁）之前与年龄呈负相关。脑膜炎组和雷特综合征组的PEA平均水平显著低于儿童对照组（p < 0.03）。脑脊液中PEA水平的改变可能与无菌性脑膜炎中多巴胺能张力的短暂变化以及神经功能损害有关，尤其是与雷特综合征中多巴胺能神经元的损害有关。
