Bowers T S, Beck B D, Karam H S
Gradient Corporation, Cambridge, Massachusetts 02138.
Risk Anal. 1994 Apr;14(2):183-9. doi: 10.1111/j.1539-6924.1994.tb00043.x.
This paper presents a model for predicting blood lead levels in adults who are exposed to elevated environmental levels of lead. The model assumes a baseline blood lead level based on average blood lead levels for adults described in two recent U.S. studies. The baseline blood level in adults arises primarily from exposure to lead in diet. Media-specific ingestion and absorption parameters are assessed for the adult population, and a biokinetic slope factor that relates uptake of lead into the body to blood lead levels is estimated. These parameters are applied to predict blood lead levels for adults exposed to a hypothetical site with elevated lead levels in soil, dust and air. Blood lead levels ranging from approximately 3-57 micrograms/dl are predicted, depending on the exposure scenarios and assumptions.
本文提出了一个用于预测暴露于环境铅水平升高环境中的成年人血铅水平的模型。该模型基于美国最近两项研究中描述的成年人平均血铅水平假设了一个基线血铅水平。成年人的基线血铅水平主要源于饮食中铅的暴露。针对成年人群评估了特定介质的摄入和吸收参数，并估算了一个将铅摄入体内与血铅水平相关的生物动力学斜率因子。这些参数被用于预测暴露于土壤、灰尘和空气中铅水平升高的假设场地的成年人血铅水平。根据暴露情景和假设，预测的血铅水平范围约为3 - 57微克/分升。
