脓毒症患者的血小板活化因子（PAF）乙酰水解酶活性、II型磷脂酶A2及细胞因子水平
Platelet-activating factor (PAF) acetylhydrolase activity, type II phospholipase A2, and cytokine levels in patients with sepsis.
作者信息
Endo S, Inada K, Yamashita H, Takakuwa T, Nakae H, Kasai T, Kikuchi M, Ogawa M, Uchida K, Yoshida M
机构信息
Critical Care & Emergency Center, Iwate Medical University, Morioka, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1994 Mar;83(3):289-95.
Platelet activating factor acetylhydrolase (PAF-AH) activity was measured in patients with sepsis, and its relationships with various cytokines and endotoxin were evaluated. PAF-AH activity was significantly higher (p = 0.0136) in 17 patients who died than 13 patients who survived. PAF-AH activity showed significant correlations with the plasma endotoxin, TNF-alpha, and IL-8 levels. These findings suggest that PAF-AH activity reflects the severity of the pathological condition.
在脓毒症患者中检测了血小板活化因子乙酰水解酶（PAF-AH）活性，并评估了其与各种细胞因子和内毒素的关系。17例死亡患者的PAF-AH活性显著高于13例存活患者（p = 0.0136）。PAF-AH活性与血浆内毒素、TNF-α和IL-8水平显著相关。这些发现表明，PAF-AH活性反映了病理状况的严重程度。
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