Nakae H, Endo S, Inada K, Yaegashi Y, Takakuwa T, Yamada Y, Arakawa N, Suzuki T, Taniguchi S, Shimamura T, Ogawa M, Teraoka H
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Mol Pathol Pharmacol. 1996 May;92(2):131-9.
We measured serum concentrations of nitrite/nitrate (NOX), type II phospholipase A2 (PLA2), leukotriene B4 (LTB4), and platelet-activating factor (PAF) in patients with sepsis. These findings were compared between patients with and without septic shock. Serum concentrations of NOX, type II PLA2, LTB4, and PAF acetylhydrolase (PAF-AH) were significantly higher in the group with septic shock (P < 0.0001; P = 0.0060; P = 0.0052; P = 0.0052), indicating the severity of the disease. There were significant correlations between the serum NOX level and serum levels of type II PLA2, LTB4, and PAF-AH (r = 0.6890, P < 0.0001; r = 0.3755, P = 0.0409; r = 0.5095, P = 0.0040, respectively). It is speculated that LTB4 and PAF, both produced with type II PLA2, interact with each other and are involved in the deterioration of pathologic features associated with sepsis. Furthermore, nitric oxide (NO) and eicosanoids interact to play an important role in vascular dilatation during septic shock.
我们测量了脓毒症患者血清中亚硝酸盐/硝酸盐（NOX）、II型磷脂酶A2（PLA2）、白三烯B4（LTB4）和血小板活化因子（PAF）的浓度。对伴有和不伴有感染性休克的患者的这些结果进行了比较。感染性休克组患者的血清NOX、II型PLA2、LTB4和PAF乙酰水解酶（PAF-AH）浓度显著更高（P<0.0001；P = 0.0060；P = 0.0052；P = 0.0052），这表明了疾病的严重程度。血清NOX水平与II型PLA2、LTB4和PAF-AH的血清水平之间存在显著相关性（r分别为0.6890，P<0.0001；r = 0.3755，P = 0.0409；r = 0.5095，P = 0.0040）。据推测，与II型PLA2一起产生的LTB4和PAF相互作用，并参与脓毒症相关病理特征的恶化。此外，一氧化氮（NO）和类花生酸相互作用，在感染性休克期间的血管扩张中起重要作用。
