Dahlman T, Sjöberg H E, Bucht E
Department of Obstetrics and Gynecology, Karolinska sjukhuset, Stockholm, Sweden.
Acta Obstet Gynecol Scand. 1994 May;73(5):393-8. doi: 10.3109/00016349409006250.
Calcium homeostasis was longitudinally followed in serum and urine throughout normal pregnancy and the puerperium in 23 healthy women. From the 14th week of gestation, samples were obtained every fourth week until the 38th week. Post partum samples were obtained on the fifth day and after eight weeks. In the serum the total calcium decreased continuously during pregnancy. The ionized calcium and phosphate levels remained unchanged and within the reference interval for non-pregnant women. The alkaline phosphatase level progressively increased and high levels were found at term. The magnesium and hematocrit values remained below, whereas the calcitonin level remained just above the reference interval throughout pregnancy. The parathyroid hormone was low initially and increased towards term but within the reference interval. The urine excretion of calcium was constantly high, close to the upper reference limit, and renal function was slightly improved. At the last sampling eight weeks after delivery, all values were within normal limits for non-pregnant women. Calcium homeostasis is considerably changed during pregnancy and non-pregnant reference limits are not often valid.
对23名健康女性整个正常孕期及产褥期的血清和尿液中的钙稳态进行了纵向跟踪研究。从妊娠第14周起，每四周采集一次样本，直至第38周。产后第5天和第8周采集样本。孕期血清总钙持续下降。离子钙和磷酸盐水平保持不变，且在非孕期女性的参考区间内。碱性磷酸酶水平逐渐升高，足月时达到较高水平。整个孕期镁和血细胞比容值低于参考区间，而降钙素水平仅略高于参考区间。甲状旁腺激素起初较低，足月时升高，但仍在参考区间内。尿钙排泄量持续较高，接近参考上限，肾功能略有改善。在产后8周的最后一次采样时，所有值均在非孕期女性的正常范围内。孕期钙稳态发生了显著变化，非孕期参考区间通常并不适用。
