伴有眼肌麻痹的脑部磁共振成像
Cerebral MR in ophthalmoplegia plus.
作者信息
Leutner C, Layer G, Zierz S, Solymosi L, Dewes W, Reiser M
机构信息
Department of Radiology, University of Bonn, Germany.
出版信息
AJNR Am J Neuroradiol. 1994 Apr;15(4):681-7.
PURPOSE
To evaluate MR patterns in ophthalmoplegia plus and correlate them with clinical symptoms.
METHODS
MR was performed on a 1.5-T whole-body scanner with T2-weighted gradient-echo and spin-echo images. The retrospective analysis included 19 patients with clinically established diagnoses of ophthalmoplegia plus.
RESULTS
Two types of cerebral MR abnormalities were found in ophthalmoplegia plus: brain atrophy and hyperintensities restricted to the white matter and basal ganglia, which appeared as either focal or diffuse areas of high signal intensity and were of strictly supratentorial location. No specific distribution was found. These findings differ markedly from infarction-like lesions found in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
CONCLUSIONS
MR is sensitive for the detection of central nervous system involvement in ophthalmoplegia plus, but findings are nonspecific. However, cerebral MR in ophthalmoplegia plus is different from other mitochondrial encephalomyopathies and underlines the clinical differentiation of mitochondrial encephalomyopathies.
目的
评估眼肌麻痹型并将其磁共振成像（MR）模式与临床症状相关联。
方法
在一台1.5-T全身扫描仪上进行MR检查，获取T2加权梯度回波和自旋回波图像。回顾性分析纳入了19例临床确诊为眼肌麻痹型的患者。
结果
在眼肌麻痹型中发现了两种类型的脑部MR异常：脑萎缩以及仅限于白质和基底节的高信号，表现为局灶性或弥漫性高信号区，且严格位于幕上。未发现特定分布。这些发现与线粒体肌病、脑病、乳酸性酸中毒和卒中样发作中发现的梗死样病变明显不同。
结论
MR对检测眼肌麻痹型中枢神经系统受累敏感，但结果不具有特异性。然而，眼肌麻痹型的脑部MR与其他线粒体脑病不同，强调了线粒体脑病的临床鉴别。
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