De Stefano N, Federico A, Arnold D L
Neurometabolic Unit, University of Siena, Italy.
Ital J Neurol Sci. 1997 Dec;18(6):331-9. doi: 10.1007/BF02048236.
The advent of magnetic resonance imaging (MRI) has revolutionized the clinical approach to the evaluation of brain white matter disorders and has contributed significantly to expansion of the concept of these diseases. MRI is very sensitive at detecting white matter lesions, but conventional T1 and T2-weighted images do not provide specific pathological information about the lesions, and correlation between MRI lesion load and clinical disability is often weak. Proton magnetic resonance spectroscopy can provide chemical-pathological information of a given tissue in vivo. The use of this MR technique in brain white matter disorders has shown to improve diagnostic classification and to provide surrogate measures useful for monitoring disease evolution and response to therapeutic intervention.
磁共振成像（MRI）的出现彻底改变了评估脑白质疾病的临床方法，并极大地推动了这些疾病概念的扩展。MRI在检测白质病变方面非常敏感，但传统的T1加权和T2加权图像并不能提供有关病变的具体病理信息，而且MRI病变负荷与临床残疾之间的相关性往往较弱。质子磁共振波谱能够在体内提供特定组织的化学病理信息。在脑白质疾病中使用这种磁共振技术已证明可改善诊断分类，并提供有助于监测疾病进展和对治疗干预反应的替代指标。
