Schwartzkroin P A
Department of Neurological Surgery/Physiology, University of Washington, Seattle 98195.
Epilepsy Res. 1994 Mar;17(3):185-92. doi: 10.1016/0920-1211(94)90049-3.
The electrophysiological characteristics of neurons in human epileptic tissue are reviewed, with emphasis on experiments employing in vitro slice analysis of human neocortex and hippocampus. There is little evidence for an alteration in intrinsic properties of cortical or hippocampal neurons in human epileptic tissue. However, data support some decrease in functional inhibition and/or increase in synaptic excitation. In slices from epileptic brain, bursting discharge can be evoked under conditions that do not elicit such discharge patterns in normal animal tissue. Most bursts are generated from prolonged and/or enhanced EPSPs; spontaneous bursting activity, and all-or-none discharge (i.e., paroxysmal depolarizations) are rarely seen in vitro. Underlying structural alterations have been correlated with increased excitability, but cause/effect relationships have not been established. These data suggest that a variety of mechanisms may contribute to epileptogenicity in human cortical tissues.
本文综述了人类癫痫组织中神经元的电生理特性，重点介绍了采用人类新皮层和海马体体外切片分析的实验。几乎没有证据表明人类癫痫组织中皮质或海马神经元的内在特性发生改变。然而，数据支持功能性抑制有所降低和/或突触兴奋性有所增加。在癫痫脑切片中，在正常动物组织中不会引发此类放电模式的条件下可诱发爆发性放电。大多数爆发是由延长和/或增强的兴奋性突触后电位产生的；体外很少见到自发爆发活动和全或无放电（即阵发性去极化）。潜在的结构改变与兴奋性增加相关，但因果关系尚未确立。这些数据表明，多种机制可能导致人类皮质组织的致痫性。
