Brown A S, Martin J F
Department of Medicine, King's College School of Medicine and Dentistry, Denmark Hill, London, UK.
Eur J Clin Invest. 1994 Feb;24 Suppl 1:9-15. doi: 10.1111/j.1365-2362.1994.tb02419.x.
Platelets form a heterogeneous population of cells produced from the uniquely large polyploid cell found in the bone marrow, the megakaryocyte. The platelet megakaryocyte axis forms a dynamic equilibrium varying in normal biology and in disease. Prolonged platelet destruction leads to the production of large platelets from large, high ploidy megakaryocytes. In vivo and ex vivo studies show that such platelets have more haemostatic potential than smaller less dense platelets. The evidence suggesting that prothrombotic changes in the megakaryocyte platelet axis precede coronary artery thrombosis and the importance of platelet reactivity in atherosclerosis will be reviewed.
血小板是由骨髓中独特的大型多倍体细胞——巨核细胞产生的异质性细胞群体。血小板-巨核细胞轴在正常生理和疾病状态下形成动态平衡。血小板长期破坏会导致大型、高倍体巨核细胞产生大型血小板。体内和体外研究表明，此类血小板比体积较小、密度较低的血小板具有更强的止血潜力。本文将综述表明巨核细胞-血小板轴的促血栓形成变化先于冠状动脉血栓形成的证据以及血小板反应性在动脉粥样硬化中的重要性。
