van der Loo B, Martin J F
University College London, London W1P 9LN, United Kingdom.
Arterioscler Thromb Vasc Biol. 1999 Mar;19(3):672-9. doi: 10.1161/01.atv.19.3.672.
Platelets are heterogeneous with respect to their size, density, and reactivity. Large platelets are more active hemostatically, and platelet volume has been found to be increased both in patients with unstable angina and with myocardial infarction. Furthermore, platelet volume is a predictor of a further ischemic event and death when measured after myocardial infarction. Platelets which are anucleate cells with no DNA are derived from their precursor, the megakaryocyte. Therefore, it is suggested that changes in platelet size are determined at thrombopoiesis in the megakaryocyte and that those changes might precede acute cardiac events. Understanding of the signaling system that controls platelet production may also further elucidate the cascade of events leading to acute vascular occlusion in some patients.
血小板在大小、密度和反应性方面具有异质性。大血小板在止血方面更活跃，并且已发现不稳定型心绞痛患者和心肌梗死患者的血小板体积均增加。此外，心肌梗死后测量时，血小板体积是进一步缺血事件和死亡的预测指标。血小板是无细胞核且无DNA的细胞，来源于其前体巨核细胞。因此，有人提出血小板大小的变化在巨核细胞的血小板生成过程中就已确定，并且这些变化可能先于急性心脏事件发生。了解控制血小板生成的信号系统也可能进一步阐明导致某些患者急性血管闭塞的一系列事件。
