Saupe S, Descamps C, Turcq B, Bégueret J
Laboratoire de Génétique, UPR 9026 Centre National de la Recherche Scientifique, Université de Bordeaux II, Talence, France.
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5927-31. doi: 10.1073/pnas.91.13.5927.
The het-c locus contains different alleles that elicit nonallelic vegetative incompatibility through specific interactions with alleles of the unlinked loci het-e and het-d. The het-c2 allele has been cloned. It encodes a 208-amino acid polypeptide that is similar to a glycolipid transfer protein purified from pig brain. Disruption of this gene drastically impairs ascospore production in homozygous crosses, and some mutants exhibit abnormal branching of apical hyphae. The protein encoded by het-c2 is essential in the biology of the fungus and may be involved in cell-wall biosynthesis.
het-c基因座包含不同的等位基因，这些等位基因通过与不连锁的het-e和het-d基因座的等位基因发生特异性相互作用，引发非等位的营养体不亲和性。het-c2等位基因已被克隆。它编码一种208个氨基酸的多肽，该多肽与从猪脑中纯化的糖脂转移蛋白相似。该基因的破坏在纯合杂交中会严重损害子囊孢子的产生，并且一些突变体表现出顶端菌丝的异常分支。het-c2编码的蛋白质在真菌生物学中至关重要，可能参与细胞壁的生物合成。
