人海马体小电导内向整流钾通道的一级结构与特性
Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus.
作者信息
Périer F, Radeke C M, Vandenberg C A
机构信息
Department of Biological Sciences, University of California, Santa Barbara 93106.
出版信息
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6240-4. doi: 10.1073/pnas.91.13.6240.
We have isolated a human hippocampus cDNA that encodes an inwardly rectifying potassium channel, termed HIR (hippocampal inward rectifier), with strong rectification characteristics. Single-channel recordings indicate that the HIR channel has an unusually small conductance (13 pS), distinguishing HIR from other cloned inward rectifiers. RNA blot analyses show that HIR transcripts are present in heart, skeletal muscle, and several different brain regions, including the hippocampus.
我们分离出了一种人类海马体cDNA，它编码一种内向整流钾通道，称为HIR（海马体内向整流器），具有很强的整流特性。单通道记录表明，HIR通道的电导异常小（13 pS），这使得HIR与其他克隆的内向整流器有所区别。RNA印迹分析表明，HIR转录本存在于心脏、骨骼肌以及包括海马体在内的几个不同脑区中。
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