Kumar A, Tandon O P, Bhattacharya A, Bose S, Kundra P
Department of Anesthesiology and Critical Care, University College of Medical Sciences, Delhi, India.
Anaesthesia. 1994 Jun;49(6):533-7. doi: 10.1111/j.1365-2044.1994.tb03529.x.
In a randomised double-blind study, 34 elderly patients (ASA grades 1-2) underwent elective intra-ocular surgery. Patients were allocated randomly to two groups to receive oral clonidine 300 micrograms or oral diazepam 10 mg 2 h before surgery. Facial block and retrobulbar block were given at 2 h after premedication. Anaesthetic recovery was assessed using a clinical recovery score (at 0, 30, 60 and 120 min after arrival in the recovery room) and brain stem auditory evoked potential responses (BAER) (immediately after operation and at 120 min after operation). In both the groups the clinical recovery scores decreased significantly at 30 and 60 min following recovery (p < 0.01). At 120 min this score returned to the pre-operative value in the clonidine group, but in the diazepam group there was a significant difference between the 2h value and pre-operative value (p < 0.05). In the clonidine group there was no significant rise in the interpeak latencies and absolute peak latencies of brain stem auditory evoked responses recorded immediately after operation and 120 min after operation. In the diazepam group, there was a significant rise in the interpeak latencies immediately after operation and 120 min after operation and a rise in absolute peak latencies (p < 0.05) immediately after operation. In the clonidine group there was a reduction (p < 0.05) in amplitude of wave V at immediately after operation. We conclude that clonidine 300 micrograms orally before surgery does not delay recovery.
在一项随机双盲研究中，34例老年患者（ASA分级1 - 2级）接受了择期眼内手术。患者被随机分为两组，在手术前2小时分别口服300微克可乐定或10毫克地西泮。术前用药2小时后进行面部阻滞和球后阻滞。使用临床恢复评分（在进入恢复室后0、30、60和120分钟）和脑干听觉诱发电位反应（BAER）（术后即刻和术后120分钟）评估麻醉恢复情况。两组患者在恢复后30和60分钟时临床恢复评分均显著降低（p < 0.01）。在120分钟时，可乐定组该评分恢复到术前值，但地西泮组2小时时的值与术前值之间存在显著差异（p < 0.05）。可乐定组术后即刻和术后120分钟记录的脑干听觉诱发电位的峰间潜伏期和绝对峰潜伏期均无显著增加。在地西泮组，术后即刻和术后120分钟峰间潜伏期显著增加，术后即刻绝对峰潜伏期增加（p < 0.05）。可乐定组术后即刻V波振幅降低（p < 0.05）。我们得出结论，术前口服300微克可乐定不会延迟恢复。
