Carretti N G, Eremita G A, Porcelli B, Paternoster D, Grella P
Clinica Ostetrica e Ginecologica, Università di Siena, Italy.
Biomed Pharmacother. 1993;47(4):161-5. doi: 10.1016/0753-3322(93)90007-8.
Serum levels of erythropoietin (EPO) were assayed by ELISA at the same time as red blood cells (RBC), hemoglobin (Hb), hematocrit (Hct), serum iron and transferrin in 136 pregnant women, divided on the basis of hemoglobin values (> or < or = 10.5 g/dl) and weeks of pregnancy (< or > or = 27th week). In the overall population, a parallel increase with weeks of pregnancy was shown by serum concentrations of EPO expressed as a logarithm (multiple R = 0.367, P < 0.0001), and transferrin levels (multiple R = 0.529, P < 0.0001). It was found that EPO levels did not differ significantly between anemic and non-anemic patients before the 27th week, but the difference became highly significant (P < 0.01) after the 27th week in favour of anemic patients. Before the 27th week, the correlations between log EPO and RBC, Hct, Hb and iron were not significant, whereas the correlation between log EPO and transferrin was significant (P < 0.01); after the 27th week, the correlations and significance of the regression found were: log EPO vs Hb (Pearson coefficient = -0.384; P < 0.001), vs Hct (Pearson coefficient = -0.370; P < 0.01), vs transferrin (Pearson coefficient = 0.392; P < 0.0001), vs iron (Pearson coefficient = -0.274, P < 0.05). In the population divided according to Hb levels, the correlation was positive and significant in both groups between log EPO and transferrin (Hb > 10.5 g/dl: Pearson coefficient = 0.524, P < 0.0001; Hb < or = 10.5: Pearson coefficient = 0.614, P < 0.0001), but was inverse and significant only in the group with Hb < or = 10.5 g/dl between log EPO and serum iron (Pearson coefficient = -0.481, P < 0.01). The variations in EPO were related to Hb levels after the 27th week of pregnancy and were closely correlated with transferrin over the whole period. The physiological mechanism of these changes is discussed.
在136名孕妇中，采用酶联免疫吸附测定法（ELISA）同时检测促红细胞生成素（EPO）的血清水平以及红细胞（RBC）、血红蛋白（Hb）、血细胞比容（Hct）、血清铁和转铁蛋白水平。根据血红蛋白值（>或<或 = 10.5 g/dl）和孕周（<或>或 = 27周）对孕妇进行分组。在总体人群中，以对数形式表示的EPO血清浓度（复相关系数R = 0.367，P < 0.0001）和转铁蛋白水平（复相关系数R = 0.529，P < 0.0001）均显示出与孕周呈平行增加。研究发现，在第27周之前，贫血和非贫血患者的EPO水平无显著差异，但在第27周之后，差异变得极为显著（P < 0.01），且有利于贫血患者。在第27周之前，log EPO与RBC、Hct、Hb和铁之间的相关性不显著，而log EPO与转铁蛋白之间的相关性显著（P < 0.01）；在第27周之后，所发现的回归相关性及显著性如下：log EPO与Hb（皮尔逊系数 = -0.384；P < 0.001）、与Hct（皮尔逊系数 = -0.370；P < 0.01）、与转铁蛋白（皮尔逊系数 = 0.392；P < 0.0001）、与铁（皮尔逊系数 = -0.274，P < 0.05）。在根据Hb水平划分的人群中，log EPO与转铁蛋白在两组中均呈正相关且显著（Hb > 10.5 g/dl：皮尔逊系数 = 0.524，P < 0.0001；Hb <或 = 10.5：皮尔逊系数 = 0.614，P < 0.0001），但仅在Hb <或 = 10.5 g/dl组中，log EPO与血清铁呈负相关且显著（皮尔逊系数 = -0.481，P < 0.01）。EPO的变化在妊娠第27周后与Hb水平相关，且在整个期间与转铁蛋白密切相关。本文讨论了这些变化的生理机制。
