[新型单针血细胞分离系统（费森尤斯AS 104 SN）的18个月使用经验]
[18 months experience with a new single needle cytapheresis system (Fresenius AS 104 SN)].
作者信息
Zeiler T, Zingsem J, Weisbach V, Zimmermann R, Wittmann G, Eckstein R
机构信息
Blutbank, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, BRD.
出版信息
Infusionsther Transfusionsmed. 1994 Apr;21(2):91-5.
BACKGROUND
Since October 1991 the third-generation cell separator Fresenius AS 104 offers a single-needle (SN) option for thrombocytapheresis. Here we present our first 18-month experience with this new single-needle system.
MATERIALS AND METHODS
We performed 395 thrombocytaphereses in 225 donors. The influence of blood flow, cycle volume, and interface position on efficacy and leukocyte contamination was evaluated.
RESULTS
395 thrombocytaphereses were performed with an average thrombocyte yield of 3.00 +/- 0.69 x 10(11) platelets and a leukocyte contamination of 1.66 +/- 3.1 x 10(8) per concentrate. Blood flow rates of 50 ml/min (vs. 60 ml/min) and an interface position of 6:2 (vs. 7:1) resulted in a lower leukocyte contamination, but without statistical significance.
CONCLUSION
The SN program of the AS 104 provides high thrombocyte yields and less leukocyte contamination than other SN systems, but 77% of the concentrates still contain more than 0.5 x 10(8) leukocytes.
背景
自1991年10月起，第三代血细胞分离机费森尤斯AS 104提供了单针（SN）血小板去除术选项。在此，我们介绍我们使用这种新型单针系统的首个18个月的经验。
材料与方法
我们对225名献血者进行了395次血小板去除术。评估了血流、循环血量和界面位置对疗效和白细胞污染的影响。
结果
进行了395次血小板去除术，平均血小板产量为3.00±0.69×10¹¹个血小板，每份浓缩物的白细胞污染为1.66±3.1×10⁸个。50毫升/分钟的血流速度（与60毫升/分钟相比）和6:2的界面位置（与7:1相比）导致白细胞污染较低，但无统计学意义。
结论
AS 104的SN程序提供了高血小板产量，且白细胞污染比其他SN系统少，但77%的浓缩物仍含有超过0.5×10⁸个白细胞。
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