幽门螺杆菌对人壁细胞组胺和卡巴胆碱刺激的胃酸分泌的影响。
Effects of Helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells.
作者信息
Jablonowski H, Hengels K J, Kraemer N, Geis G, Opferkuch W, Strohmeyer G
机构信息
Department of Gastroenterology, Heinrich-Heine-University, Düsseldorf, Germany.
出版信息
Gut. 1994 Jun;35(6):755-7. doi: 10.1136/gut.35.6.755.
Helicobacter pylori (H pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiological pathways by which H pylori interacts with acid secretion are still unclear. The effects of H pylori on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different H pylori strains. Omeprazole and sonicates of Campylobacter jejuni served as positive and negative controls, respectively. Two of four H pylori strains reduced hydrochloric acid sequestration within the parietal cells significantly and in a dose dependent manner in up to 80%. Interaction with acid secretion may therefore constitute a factor contributing to a distinct pathogenicity of H pylori strains.
幽门螺杆菌（H pylori）感染与胃黏膜分泌减少、正常及分泌过多等紊乱情况相关。幽门螺杆菌与胃酸分泌相互作用的病理生理途径仍不清楚。作为胃酸分泌的间接检测方法，研究了幽门螺杆菌对人壁细胞摄取（14C）氨基比林的影响。用次最大浓度的组胺或卡巴胆碱刺激分离的泌酸腺，并与不同幽门螺杆菌菌株的超声裂解物一起孵育。奥美拉唑和空肠弯曲菌超声裂解物分别作为阳性和阴性对照。四株幽门螺杆菌中有两株能显著且呈剂量依赖性地使壁细胞内盐酸摄取减少，最高可达80%。因此，与胃酸分泌的相互作用可能是导致幽门螺杆菌菌株具有独特致病性的一个因素。
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