人类2号染色体上的基因座到绵羊2号染色体的区域定位。

Regional mapping of loci from human chromosome 2q to sheep chromosome 2q.

作者信息

Ansari H A, Pearce P D, Maher D W, Malcolm A A, Wood N J, Phua S H, Broad T E

机构信息

AgResearch, Grasslands Research Centre, Palmerston North, New Zealand.

出版信息

Genomics. 1994 Mar 1;20(1):122-4. doi: 10.1006/geno.1994.1137.

DOI:10.1006/geno.1994.1137

PMID:8020939

Abstract

The human chromosome 2q loci, fibronectin 1 (FN1), the alpha 1 chain of type III collagen (COL3A1), and the delta subunit of the muscle acetylcholine receptor (CHRND) have been regionally assigned to sheep chromosome 2q by in situ hybridization. COL3A1 is pericentromeric (2q12-q21), while FN1 and CHRND are in the subterminal region at 2q41-q44 and 2q42-qter, respectively. The mapping of FN1 assigns the sheep syntenic group U11, which contains FN1, villin 1 (VIL1), isocitrate dehydrogenase 1 (IDH1), and gamma subunit of the muscle acetylcholine receptor (CHRNG), to sheep chromosome 2q. Inhibin-alpha (INHA) is also assigned to sheep chromosome 2q as FN1 and INHA compose sheep linkage group 3. These seven loci are members of a conserved chromosomal segment in human, mouse, and sheep.

摘要

通过原位杂交技术，已将人染色体2q位点、纤连蛋白1（FN1）、III型胶原蛋白α1链（COL3A1）和肌肉乙酰胆碱受体δ亚基（CHRND）定位到绵羊染色体2q上。COL3A1位于着丝粒周围（2q12-q21），而FN1和CHRND分别位于2q41-q44和2q42-qter的亚末端区域。FN1的定位将包含FN1、绒毛蛋白1（VIL1）、异柠檬酸脱氢酶1（IDH1）和肌肉乙酰胆碱受体γ亚基（CHRNG）的绵羊同线群U11定位到绵羊染色体2q上。抑制素α（INHA）也被定位到绵羊染色体2q上，因为FN1和INHA构成绵羊连锁群3。这七个位点是人类、小鼠和绵羊中保守染色体片段的成员。