Broad T E, Burkin D J, Cambridge L M, Lewis P E, Maher D W, Ansari H A, Pearce P D, Jones C
Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand.
Mamm Genome. 1995 Mar;6(3):202-5. doi: 10.1007/BF00293014.
Eight new loci have been assigned to sheep Chromosome (Chr) 1q by use of a chromosomally characterized minipanel of sheep x hamster cell hybrids. Four loci, which have been mapped to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1). The other four loci, on human Chr 21, include interferon alpha receptor (IFNAR); interferon inducible protein p78, murine (MX1); collagen type VI, alpha 1 (COL6A1); and S100 protein, beta polypeptide (S100B). All of these loci, except GLUT2 and MX1, have been mapped onto bovine Chr 1 or are syntenic with loci on this chromosome. The in situ localization of transferrin (TF) to sheep Chr 1q42-q45 confirms our previous assignment of this locus and independently anchors the eight new syntenic loci to sheep Chr 1q.
通过使用一组经染色体特征鉴定的绵羊×仓鼠细胞杂交小面板，已将8个新基因座定位到绵羊染色体（Chr）1q上。已定位到人类Chr 3q远端区域的4个基因座分别是铜蓝蛋白（CP）、蔗糖酶异麦芽糖酶（SI）、葡萄糖转运蛋白2（GLUT2）和异位病毒整合位点1（EVI1）。位于人类Chr 21上的其他4个基因座包括干扰素α受体（IFNAR）；小鼠干扰素诱导蛋白p78（MX1）；VI型胶原α1（COL6A1）；以及S100蛋白β多肽（S100B）。除GLUT2和MX1外，所有这些基因座都已定位到牛Chr 1上，或与该染色体上的基因座同线。转铁蛋白（TF）在绵羊Chr 1q42 - q45上的原位定位证实了我们之前对该基因座的定位，并独立地将这8个新的同线基因座锚定到绵羊Chr 1q上。
