Hendershot L M, Valentine V A, Lee A S, Morris S W, Shapiro D N
Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.
Genomics. 1994 Mar 15;20(2):281-4. doi: 10.1006/geno.1994.1166.
BiP/GRP78 is a member of the HSP70 family involved in the folding and assembly of proteins in the endoplasmic reticulum. Using PCR amplification of DNA from human x rodent somatic hybrids that segregate human chromosomes in conjunction with fluorescence in situ hybridization, we have assigned GRP78 to chromosome 9q34. This is in agreement with the localization of murine and bovine homologues based on the high degree of synteny in this region. Several interesting genes and disorders map to this region and are discussed.
结合蛋白/葡萄糖调节蛋白78（BiP/GRP78）是热休克蛋白70（HSP70）家族的一员，参与内质网中蛋白质的折叠和组装。我们利用从分离人类染色体的人-啮齿动物体细胞杂种中进行DNA的PCR扩增，并结合荧光原位杂交技术，将GRP78定位于9号染色体长臂3区4带（9q34）。基于该区域高度的同线性，这与小鼠和牛的同源物定位一致。一些有趣的基因和疾病定位于此区域并进行了讨论。
