Louon A, Reddy V G
College of Medicine, Sultan Qaboos University, Muscat, Sultanate of Oman.
Acta Anaesthesiol Scand. 1994 Apr;38(3):259-61. doi: 10.1111/j.1399-6576.1994.tb03885.x.
We have studied the sedation achieved with a mixture of midazolam (0.56 mg/kg-1) and ketamine (5 mg/kg-1) administered nasally in 30 children weighing less than 16 kg undergoing computerised tomography. Assessment was two fold using a visual analogue scale; the radiologist/radiographer rated the exam from "failed examination" to "perfect working conditions" while the anesthetist's assessment ranged from "poor sedation" to "perfect sedation with clinical well being". This new method proved to be effective alone in 83% of the cases and there were no complications. The rapid onset obtained after intranasal midazolam and ketamine offers advantages over orally or rectally administered drugs. The absence of respiratory depression and oxygen desaturation suggests that this technique is safe and efficient in the CT room with its particular working conditions.
我们研究了在30名体重不足16公斤、接受计算机断层扫描的儿童中，经鼻给予咪达唑仑（0.56毫克/千克-1）和氯胺酮（5毫克/千克-1）混合药物所达到的镇静效果。使用视觉模拟量表进行了两方面的评估；放射科医生/放射技师将检查从“检查失败”到“完美的工作条件”进行评分，而麻醉师的评估范围则从“镇静效果差”到“临床状态良好的完美镇静”。这种新方法在83%的病例中单独使用时被证明是有效的且无并发症。经鼻给予咪达唑仑和氯胺酮后起效迅速，这比口服或直肠给药具有优势。无呼吸抑制和氧饱和度降低表明该技术在CT室特殊的工作条件下是安全有效的。
