Harmathy Z, Konkoly Thege I
ELTE Szervetlen és Analtikai Kémiai Tanszék, Budapest.
Acta Pharm Hung. 1994 Jan;64(1):9-15.
Main applications of modern thermal methods in the pharmaceutical analysis are reviewed. While these methods are widely employed in pharmaceutical industry, they are only recommended--but not prescribed--in the general part of the VIIth Pharmacopoea Hungarica and consequently, this field is practically unknown for the pharmacists. The aim of this paper is to call attention to the advantage of the application of modern thermal methods (DTA, TG, DSC) in contrast to the classical ones. They permit a quick and accurate measurement of the melting point, the determination of purity and eutectic point, to clear up the possibility of conditions for the development of polymorphic modifications, and to follow the process of loosing the water of crystallization.
