Orozco H, Mercado M A, Takahashi T, Rojas G, Hernández J, Tielve M
Portal Hypertension Clinic, Instituto Nacional de la Nutricion, Tlalpan, Mexico, D.F., Mexico.
Am J Surg. 1994 Jul;168(1):10-4. doi: 10.1016/s0002-9610(05)80062-5.
Between 1979 and 1991, 156 patients with histologically proven liver cirrhosis, good liver function, and bleeding portal hypertension underwent operation with portal blood flow preserving procedures (selective shunts: 101; Sugiura-Futagawa: 55). Long-term results of the procedures and the quality of life of the 145 patients who survived the operation were studied. During the observation period (range 3 to 156 months), 28 patients died. The main causes of death were liver failure and hepatoma. Twenty-three patients were lost for follow-up. Twenty-six patients (18%) developed 1 or more encephalopathic episodes. Four patients (3%) experienced rebleeding. One hundred eight patients (74%) had a good quality of life, and 26 (18%) had a poor quality of life. Eleven (15%) of 73 patients with a history of alcoholism continued drinking. Five-year survival for the selective shunt group was 81% and for the devascularization group was 83%. In 81% of the patients, portal blood flow was maintained. It is concluded that both procedures are effective in the long-term. Most patients are able to rehabilitate from the use of alcohol, and most of them have a good quality of life. For patients with good liver function (whose main problem is bleeding), surgery is the best choice of treatment.
1979年至1991年间,156例经组织学证实为肝硬化、肝功能良好且有门静脉高压出血的患者接受了保留门静脉血流手术(选择性分流术:101例;杉浦-二川术:55例)。对手术存活的145例患者的手术长期效果及生活质量进行了研究。在观察期(3至156个月)内,28例患者死亡。主要死亡原因是肝衰竭和肝癌。23例患者失访。26例患者(18%)发生1次或多次肝性脑病发作。4例患者(3%)再次出血。108例患者(74%)生活质量良好,26例患者(18%)生活质量较差。73例有酗酒史的患者中,11例(15%)仍在饮酒。选择性分流术组的5年生存率为81%,去血管化组为83%。81%的患者门静脉血流得以维持。结论是两种手术长期效果均有效。大多数患者能够戒除酒精,且大多数患者生活质量良好。对于肝功能良好(主要问题是出血)的患者,手术是最佳治疗选择。