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人工瓣膜心内膜炎合并瓣环脓肿。手术治疗及长期结果。

Prosthetic valve endocarditis with ring abscesses. Surgical management and long-term results.

作者信息

Jault F, Gandjbakhch I, Chastre J C, Levasseur J P, Bors V, Gibert C, Pavie A, Cabrol C

机构信息

Department of Cardiovascular Surgery, Pitie's Hospital, Paris, France.

出版信息

J Thorac Cardiovasc Surg. 1993 Jun;105(6):1106-13.

PMID:8501938
Abstract

From January 1978 to December 1988, 71 patients underwent surgical intervention at our institution for prosthetic valve endocarditis with ring abscesses. These procedures involved 59 aortic prostheses and 12 mitral prostheses. No causative agent could be identified in 19 patients (26.7%). The operation was performed during antibiotic therapy in 63 patients and after a planned course of antibiotic therapy in 8 patients. At the aortic level, abscesses were remedied by suturing in 3 cases, by pericardial patches in 34 cases, and by complex procedures in 22 cases (subcoronary valved conduit in 11 cases, supracoronary valved conduit with coronary bypass grafts in 10 cases, apicoaortic valved conduit in 1 case). At the mitral level, ring abscesses were cured in 10 cases by intraatrial implantation of the prosthesis. In one case, the prosthesis was anchored inside the left ventricle; and in one case the valve could be seated on the anulus. The overall operative mortality rate was 17%. Long-term survival was 54% +/- 8% at 6 years. Fifteen (26%) of the survivors needed a third valve replacement (four operative deaths); a complex reconstruction was performed in seven patients. Better detection of ring abscesses and earlier surgical intervention before annular destruction and hemodynamic failure can improve the operative mortality rate for prosthetic valve endocarditis. When it is necessary, complex reconstruction, in spite of a high mortality rate, seems to eradicate the infectious seat, and the outlook for the patient's condition appears good.

摘要

1978年1月至1988年12月,我院71例人工瓣膜心内膜炎合并瓣环脓肿患者接受了外科手术治疗。这些手术涉及59个主动脉人工瓣膜和12个二尖瓣人工瓣膜。19例(26.7%)患者未发现病原体。63例患者在抗生素治疗期间接受手术,8例患者在完成计划的抗生素疗程后接受手术。在主动脉瓣水平,3例脓肿通过缝合修复,34例通过心包补片修复,22例通过复杂手术修复(11例采用冠状动脉下带瓣管道,10例采用冠状动脉上带瓣管道并进行冠状动脉搭桥,1例采用心尖主动脉带瓣管道)。在二尖瓣水平,10例瓣环脓肿通过心房内植入人工瓣膜治愈。1例患者人工瓣膜固定于左心室内;1例患者瓣膜可安置于瓣环上。总体手术死亡率为17%。6年长期生存率为54%±8%。15例(26%)幸存者需要再次更换瓣膜(4例手术死亡);7例患者进行了复杂重建。更好地检测瓣环脓肿并在瓣环破坏和血流动力学衰竭之前更早地进行手术干预可提高人工瓣膜心内膜炎的手术死亡率。必要时,尽管死亡率高,但复杂重建似乎可根除感染灶,患者病情前景良好。

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