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局部麻醉药对人角膜的毒性副作用。

Toxic side effects of local anaesthetics on the human cornea.

作者信息

Boljka M, Kolar G, Vidensek J

机构信息

Department of Ophthalmology, University Ljubljana, Slovenija.

出版信息

Br J Ophthalmol. 1994 May;78(5):386-9. doi: 10.1136/bjo.78.5.386.

DOI:10.1136/bjo.78.5.386
PMID:8025073
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC504793/
Abstract

The cytotoxic effects of 0.5% amethocaine (tetracaine) on the human cornea were investigated by scanning electron microscopy. The ultrastructural examination of epithelial cells showed damage of the cell membrane, rare-faction and loss of microvilli, deposits of amethocaine on the corneal surface and accelerated desquamation of superficial epithelial cells.

摘要

通过扫描电子显微镜研究了0.5%丁卡因对人角膜的细胞毒性作用。上皮细胞的超微结构检查显示细胞膜受损、微绒毛稀少和缺失、丁卡因在角膜表面沉积以及表层上皮细胞加速脱落。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/b92fea71aadb/brjopthal00029-0064-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/5a978db1b1c1/brjopthal00029-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/a2edb0bd06e3/brjopthal00029-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/04b7dee496db/brjopthal00029-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/b3bc733f9b8d/brjopthal00029-0063-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/6ed2d9404a3d/brjopthal00029-0063-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/6035bca5502e/brjopthal00029-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/3facf0a015ac/brjopthal00029-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/b92fea71aadb/brjopthal00029-0064-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/5a978db1b1c1/brjopthal00029-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/a2edb0bd06e3/brjopthal00029-0062-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/04b7dee496db/brjopthal00029-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/b3bc733f9b8d/brjopthal00029-0063-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/6ed2d9404a3d/brjopthal00029-0063-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/6035bca5502e/brjopthal00029-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/3facf0a015ac/brjopthal00029-0064-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c511/504793/b92fea71aadb/brjopthal00029-0064-c.jpg

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本文引用的文献

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The fine structure of the corneal epithelium.角膜上皮的精细结构。
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Differentiating Urgent and Emergent Causes of Acute Red Eye for the Emergency Physician.急诊科医生鉴别急性红眼的紧急和急诊病因
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Cytotoxic effect and possible mechanisms of Tetracaine on human corneal epithelial cells in vitro.丁卡因对人角膜上皮细胞的体外细胞毒性作用及可能机制
Int J Ophthalmol. 2016 Apr 18;9(4):497-504. doi: 10.18240/ijo.2016.04.04. eCollection 2016.
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Topical ocular anesthetic abuse among Iranian welders: time for action.伊朗焊工中局部眼部麻醉剂滥用问题：是采取行动的时候了。
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[Anesthetic keratitis (author's transl)].[麻醉性角膜炎（作者译）]
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[Corneal damage due to novesine].[诺维辛导致的角膜损伤]
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[Serious damage to the eye by Novesine].
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Molecular mechanisms of local anesthesia: a review.局部麻醉的分子机制：综述
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