Timms L M, Marshall R N, Breslin M F
Central Veterinary Laboratory, New Haw, Weybridge, Surrey.
Br Vet J. 1994 Jan-Feb;150(1):93-102. doi: 10.1016/S0007-1935(05)80101-0.
An inactivated Salmonella enteritidis PT4 vaccine, containing 10(9) cfu ml-1 and 75% oil-adjuvant, was used in a laboratory and field trial. Vaccination at day old and 4 weeks subcutaneously provided good protection against massive challenge with 10(8) cfu of virulent organisms administered intravenously at 8, 12 and 16 weeks of age. The degree of protection was assessed according to the severity of the clinical signs, mortality, postmortem lesions and the recovery of the challenge organisms from postmortem material in vaccinated and unvaccinated challenged birds.
一种含有10⁹cfu/ml且油佐剂含量为75%的灭活肠炎沙门氏菌PT4疫苗，用于实验室和田间试验。在雏鸡一日龄和4周龄时皮下接种该疫苗，能有效保护雏鸡免受在8、12和16周龄时静脉注射10⁸cfu强毒微生物的大规模攻击。根据接种和未接种疫苗的受攻击鸡的临床症状严重程度、死亡率、死后病变以及从死后材料中分离出攻击微生物的情况来评估保护程度。
