Tsuda N, Negoro K, Morimatsu M
Department of Neurology, Yamaguchi University School of Medicine.
Rinsho Shinkeigaku. 1994 Apr;34(4):388-90.
We report an 80-year-old woman with hemichorea probably due to amantadine hydrochloride. She visited our hospital because of gait disturbance and decreased mental activity. She was diagnosed as multiple cerebral infarctions and treated with 100 mg/day of amantadine hydrochloride. After two weeks she showed choreic movement of the face and right arm and leg. Haloperidol was administered and her choreic movement disappeared. Brain MRI showed multiple cerebral infarctions in the white matter. There was no lesion in the left basal ganglia. SPECT showed hyperperfusion in the left basal ganglia when choreic movement appeared. After choreic movement disappeared, SPECT showed no asymmetrical blood flow. These findings suggest hemichorea was related to hyperfunction of dopaminergic neurons in the left basal ganglia.
我们报告一名80岁女性，其偏侧舞蹈症可能由盐酸金刚烷胺所致。她因步态障碍和精神活动减退前来我院就诊。她被诊断为多发性脑梗死，并接受每日100毫克盐酸金刚烷胺治疗。两周后，她出现面部及右侧手臂和腿部的舞蹈样动作。给予氟哌啶醇治疗后，其舞蹈样动作消失。脑部MRI显示白质多发脑梗死。左侧基底节无病变。舞蹈样动作出现时，单光子发射计算机断层扫描（SPECT）显示左侧基底节血流灌注增加。舞蹈样动作消失后，SPECT显示无血流不对称情况。这些发现提示偏侧舞蹈症与左侧基底节多巴胺能神经元功能亢进有关。
