二氮嗪和拉贝洛尔快速降低高血压患者体循环动脉压对脑血流量影响的比较：初步研究结果
Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.
作者信息
Pearson R M, Griffith D N, Woollard M, James I M, Havard C W
出版信息
Br J Clin Pharmacol. 1979;8(Suppl 2):195S-198S.
Abstract
1 Diazoxide 300 mg and labetalol 150 mg were each injected intravenously on separate occasions into five patients with essentail hypertension. The reduction in BP caused by labetalol was slightly greater than that produced by diazoxide. 2 In contrast the reduction in cerebral blood flow (CBF) by labetalol was not statistically significant, whereas diazoxide gave a greater and statistically significant reduction in CBF. 3 These observations suggest that labetalol may have an advantage over diazoxide for the rapid reduction in BP.
摘要
- 在五个原发性高血压患者中，分别在不同时间静脉注射300毫克二氮嗪和150毫克拉贝洛尔。拉贝洛尔引起的血压降低略大于二氮嗪。2. 相比之下，拉贝洛尔引起的脑血流量（CBF）降低无统计学意义，而二氮嗪使CBF有更大且具有统计学意义的降低。3. 这些观察结果表明，在快速降低血压方面，拉贝洛尔可能优于二氮嗪。
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本文引用的文献
1
Protein binding and vascular activity of diazoxide.二氮嗪的蛋白质结合及血管活性
N Engl J Med. 1969 Nov 20;281(21):1141-5. doi: 10.1056/NEJM196911202812102.
2
Autoregulation of brain circulation in severe arterial hypertension.重度动脉高血压时脑循环的自动调节
Br Med J. 1973 Mar 3;1(5852):507-10. doi: 10.1136/bmj.1.5852.507.
3
Side effects of diazoxide.
JAMA. 1976 Jan 19;235(3):275-6.
4
The construction and use of nomograms for cerebral blood flow calculation using a 133Xe inhalation technique.
Phys Med Biol. 1976 May;21(3):406-13. doi: 10.1088/0031-9155/21/3/006.
5
Intradialytic measurement of cardiac output by thermodilution and impedance cardiography.
Clin Nephrol. 1977 Feb;7(2):61-4.
6
Some haemodynamic effects of compound AH 5158 compared with propranolol, propranolol plus hydrallazine, and diazoxide: the use of AH 5158 in the treatment of hypertension.与普萘洛尔、普萘洛尔加肼屈嗪及二氮嗪相比，化合物AH 5158的一些血流动力学效应：AH 5158在高血压治疗中的应用
Clin Sci Mol Med Suppl. 1975 Jun;2:97s-100s. doi: 10.1042/cs048097s.
7
8
Two minute slope inhalation technique for cerebral blood flow measurement in man. 2. Clinical appraisal.用于人体脑血流测量的两分钟斜坡吸入技术。2. 临床评估。
J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):147-51. doi: 10.1136/jnnp.39.2.147.
9
Measurement of cardiac output by impedance cardiography in patients with myocardial infarction. Comparative evaluation of impedance and dye dilution methods.
Scand J Clin Lab Invest. 1976 Jan;36(1):29-34. doi: 10.1080/00365517609068015.
10
Hypotensive sequelae of diazoxide and hydralazine therapy.
JAMA. 1977 Jan 17;237(3):264-5.
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