Hicks M J, Flaitz C M, Wong M E, McDaniel R K, Cagle P T
Department of Pathology, Baylor College of Medicine, Houston, Texas.
Head Neck. 1994 May-Jun;16(3):272-7. doi: 10.1002/hed.2880160311.
The calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm which was first described by Pindborg in 1955 and accounts for less than 1% of all odontogenic lesions. Recently, a clear cell variant of CEOT has been identified with only eight well-documented cases in the literature. We present an additional case of clear cell CEOT of the mandible and review the salient clinical, radiologic, and histopathologic features of this entity and CEOTs in general. The differential diagnosis of clear cell tumors in the mandible includes: clear cell odontogenic tumor, clear cell ameloblastoma (odontogenic carcinoma), metastatic clear cell adenocarcinoma, primary intraosseous mucoepidermoid carcinoma, acinic cell carcinoma, epithelial-myoepithelial carcinoma, clear cell salivary gland tumors, and clear cell variant of squamous cell carcinoma. Because of the belief that clear cell odontogenic tumors are locally aggressive neoplasms, definitive resection of the entire mass with tumor-free surgical margins and long-term follow-up are recommended.
钙化上皮性牙源性肿瘤（CEOT）是一种罕见的良性牙源性肿瘤，于1955年由平德伯格首次描述，占所有牙源性病变的比例不到1%。最近，已鉴定出CEOT的透明细胞变体，文献中仅有8例记录完整的病例。我们报告1例下颌骨透明细胞CEOT的病例，并综述该实体及一般CEOT的显著临床、放射学和组织病理学特征。下颌骨透明细胞肿瘤的鉴别诊断包括：透明细胞牙源性肿瘤、透明细胞成釉细胞瘤（牙源性癌）、转移性透明细胞腺癌、原发性骨内黏液表皮样癌、腺泡细胞癌、上皮-肌上皮癌、透明细胞唾液腺肿瘤以及鳞状细胞癌的透明细胞变体。由于认为透明细胞牙源性肿瘤是具有局部侵袭性的肿瘤，建议完整切除整个肿物，并确保手术切缘无肿瘤组织，同时进行长期随访。
