Veness M J, Morgan G, Collins A P, Walker D M
Department of Radiation Oncology, Westmead Hospital, Westmead, New South Wales, 2145, Sydney, Australia.
Head Neck. 2001 Aug;23(8):692-6. doi: 10.1002/hed.1097.
Pindborg tumors (calcifying epithelial odontogenic tumors) are uncommon neoplasms of odontogenic origin most often located in the posterior mandible. First described in detail in 1955 by Pindborg, these tumors are considered benign but can be locally aggressive in nature, with recurrence rates of 10% to 15% reported. The malignant form of this tumor is exceedingly rare.
We describe the case of a 64-year-old woman initially treated for a painful infected left mandibular third molar. The patient underwent extraction of the tooth and excision of an associated soft tissue component. Subsequent histologic review identified a Pindborg tumor of the left posterior mandible.
After initial excision, this tumor recurred twice, with the recurrences exhibiting a progression to a malignant Pindborg tumor (odontogenic carcinoma) with vascular invasion and spread to a cervical lymph node. Further treatment involved radical surgery and adjuvant radiotherapy. At last review 12 months after treatment, the patient was disease free.
This article describes only the second case of odontogenic carcinoma. The transformation from benign to malignant histologic findings has not previously been documented in this tumor. The salient clinical features of this case are presented along with supportive pathologic and radiologic evidence.
平博肿瘤（钙化上皮性牙源性肿瘤）是一种罕见的牙源性肿瘤，最常位于下颌骨后部。1955年平博首次对其进行详细描述，这些肿瘤被认为是良性的，但本质上可能具有局部侵袭性，报道的复发率为10%至15%。该肿瘤的恶性形式极为罕见。
我们描述了一名64岁女性的病例，她最初因左侧下颌第三磨牙疼痛伴感染接受治疗。患者接受了牙齿拔除及相关软组织成分切除。随后的组织学检查发现左侧下颌骨后部有一个平博肿瘤。
初次切除后，该肿瘤复发两次，复发时进展为伴有血管侵犯并扩散至颈部淋巴结的恶性平博肿瘤（牙源性癌）。进一步的治疗包括根治性手术和辅助放疗。在治疗后12个月的最后一次复查时，患者无疾病迹象。
本文仅描述了第二例牙源性癌病例。此前该肿瘤尚未有从良性组织学表现转变为恶性的记录。本文呈现了该病例的显著临床特征以及支持性的病理和影像学证据。
