Di Giuseppe Eréndira C, Ferréol Bah Homègnon A, Gomes Júnior Erival A, Dos Santos Nathália R, Costa Daisy O, Martinez Victor O, Macêdo Pires Elis, Araújo Santana João V, da S Cerqueira Filipe, Menezes-Filho José A
Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Institute of Collective Health, Federal University of Bahia, Salvador 40170-115, Brazil.
Toxics. 2024 Mar 30;12(4):261. doi: 10.3390/toxics12040261.
Kidney dysfunction is increasing worldwide and is exacerbated by exposure to toxic metals. Also, pregnancy poses an overload on kidney function. We investigated how blood lead (PbB) and cadmium (CdB) levels were associated with kidney function in pregnant women from Recôncavo Baiano, Brazil, during their second trimester. In this cross-sectional study, the estimated glomerular filtration rate (eGFR) was calculated from serum creatinine and whole blood metal levels were measured by graphite furnace atomic absorption spectrophotometry in 136 volunteers. Sociodemographic data were collected using semi-structured questionnaires. The medians (IQR) of PbB, CdB, and eGFR were 0.85 µg/dL (0.45-1.75), 0.55 µg/L (0.08-0.91), and 121.8 mL/min/1.73 m (106.0-127.9), respectively. PbB medians were significantly higher in the eGFR < 90 group at 2.00 µg/dL (0.83, 3.10). After age-adjusted logistic regression, pregnant women with elevated PbB levels had decreased eGFR (OR = 1.82; 95%-CI, 1.14-3.14). However, the participants with elevated PbB levels who reported consuming alcohol during pregnancy or had CdB in the highest tertile had higher odds of reduced eGFR (OR = 2.44; 95%-CI, 1.30-5.47) and (OR = 11.22; 95% CI, 2.53-103.51), respectively. These results suggest that low Pb exposure may affect kidney function in pregnant women and calls for further investigation into toxic metal co-exposures on kidney function during pregnancy in at-risk communities.
全球范围内，肾功能障碍正在增加，接触有毒金属会使其加剧。此外，怀孕会给肾功能带来负担。我们调查了巴西巴伊亚州雷康卡沃地区孕妇在孕中期时血铅（PbB）和镉（CdB）水平与肾功能之间的关联。在这项横断面研究中，通过血清肌酐计算估计肾小球滤过率（eGFR），并采用石墨炉原子吸收分光光度法对136名志愿者的全血金属水平进行测量。使用半结构化问卷收集社会人口学数据。PbB、CdB和eGFR的中位数（四分位间距）分别为0.85 µg/dL（0.45 - 1.75）、0.55 µg/L（0.08 - 0.91）和121.8 mL/min/1.73 m²（106.0 - 127.9）。在eGFR < 90的组中，PbB中位数显著更高，为2.00 µg/dL（0.83，3.10）。经过年龄调整的逻辑回归分析，血铅水平升高的孕妇eGFR降低（比值比 = 1.82；95%置信区间，1.14 - 3.14）。然而，报告在孕期饮酒的血铅水平升高的参与者或CdB处于最高三分位数的参与者，其eGFR降低的几率分别更高（比值比 = 2.44；95%置信区间，1.30 - 5.47）和（比值比 = 11.22；95%置信区间，2.53 - 103.51）。这些结果表明，低铅暴露可能会影响孕妇的肾功能，并呼吁对高危社区孕期有毒金属共同暴露对肾功能的影响进行进一步调查。
