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对泌尿外科肿瘤免疫诊断的一项贡献。

A contribution to immunological tumour diagnostics in urology.

作者信息

Günther M, Friedrich A, Erdmann T, Jenssen H L, Werner H, Seyfarth M, Köhler H

出版信息

Int Urol Nephrol. 1978;10(2):111-5. doi: 10.1007/BF02082130.

DOI:10.1007/BF02082130
PMID:81191
Abstract

Fifty-four patients with malignant and other diseases of the urinary bladder and the prostate were examined for lymphocyte sensitization by means of electrophoretic mobility test (EM test). In this antigens from brain tissue (EF) and from malignomas of kidney, urinary bladder and prostate were used. Positive HEP values were obtained in 40 patients out of 42 with malignant tumours and in 5 patients out of 12 with other kidney diseases. With the corresponding tumour-associated antigens (TAA) in the EM-test, the histological tumour diagnosis could be confirmed in every case. Positive findings after using EF as well as the corresponding TAA are with great probability an indication of a malignant disease.

摘要

对54例患有膀胱和前列腺恶性及其他疾病的患者,通过电泳迁移率试验(EM试验)检测淋巴细胞致敏情况。在该试验中,使用了脑组织抗原(EF)以及肾脏、膀胱和前列腺恶性肿瘤的抗原。42例恶性肿瘤患者中有40例获得了阳性HEP值,12例患有其他肾脏疾病的患者中有5例获得阳性HEP值。在EM试验中,使用相应的肿瘤相关抗原(TAA),在每种情况下都能确诊组织学肿瘤诊断。使用EF以及相应的TAA后得到的阳性结果极有可能表明患有恶性疾病。

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1
A contribution to immunological tumour diagnostics in urology.对泌尿外科肿瘤免疫诊断的一项贡献。
Int Urol Nephrol. 1978;10(2):111-5. doi: 10.1007/BF02082130.
2
[Immunodiagnosis of urologic tumors].[泌尿系统肿瘤的免疫诊断]
Z Urol Nephrol. 1977 May;70(4):225-30.
3
[A contribution to the early diagnosis and differential diagnosis of bladder neoplasms by means of immunological methods].[通过免疫学方法对膀胱肿瘤进行早期诊断和鉴别诊断的一项贡献]
Z Urol Nephrol. 1978 Feb;71(2):81-7.
4
Evaluation of cellular immunologic responsiveness in the clinical management of patients with prostatic cancer. III. Inhibition of leucocyte migration.前列腺癌患者临床管理中细胞免疫反应性的评估。III. 白细胞迁移的抑制
Urol Int. 1976;31(6):444-58. doi: 10.1159/000280080.
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Effect of human seminal plasma on tumour-associated immunity in patients with adenocarcinoma of the prostate.人精浆对前列腺腺癌患者肿瘤相关免疫的影响。
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Immunocytochemical localisation of prostate-specific antigen: specificity and application to clinical practice.前列腺特异性抗原的免疫细胞化学定位:特异性及其在临床实践中的应用。
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[The value of histochemical detection of prostate specific antigen].[前列腺特异性抗原的组织化学检测价值]
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Cell-mediated immunity in prostatic cancer and its diagnostic relevancy.前列腺癌中的细胞介导免疫及其诊断相关性。
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A preliminary report on the use of transfer factor for treating stage D3 hormone-unresponsive metastatic prostate cancer.关于使用转移因子治疗D3期激素无反应性转移性前列腺癌的初步报告。
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Modulatory effects of oestrogen on immunological responsiveness. II. Suppression of tumour-associated immunity in patients with prostatic cancer.雌激素对免疫反应性的调节作用。II. 前列腺癌患者肿瘤相关免疫的抑制
Clin Exp Immunol. 1979 Oct;38(1):83-91.

引用本文的文献

1
Cell electrophoresis for diagnostic purposes. I. Diagnostic value of the electrophoretic mobility test (EMT) for the detection of gynaecological malignancies.用于诊断目的的细胞电泳。I. 电泳迁移率测试(EMT)在检测妇科恶性肿瘤中的诊断价值。
Br J Cancer. 1981 May;43(5):588-97. doi: 10.1038/bjc.1981.88.

本文引用的文献

1
Transformation of lymphocytes from patients with multiple sclerosis. Use of encephalitogen of human origin, with a report of a trial of immunosuppressive therapy in multiple sclerosis.
Arch Neurol. 1970 Jul;23(1):32-40. doi: 10.1001/archneur.1970.00480250036006.
2
The concept of immunological surveillance.免疫监视的概念。
Prog Exp Tumor Res. 1970;13:1-27. doi: 10.1159/000386035.
3
Cell-mediated immunity to human solid tumors: in vitro detection by lymphocyte blastogenic responses to cell-associated and solubilized tumor antigens.针对人类实体瘤的细胞介导免疫:通过淋巴细胞对细胞相关和可溶性肿瘤抗原的增殖反应进行体外检测。
Natl Cancer Inst Monogr. 1973 Jun;37:167-76.
4
Tumor-specific antigen solubilized by hypertonic potassium chloride.通过高渗氯化钾溶解的肿瘤特异性抗原。
J Natl Cancer Inst. 1971 Sep;47(3):703-9.
5
Macrophage-electrophoretic-mobility (M.E.M.) test for malignant disease. An independent confirmation.巨噬细胞电泳迁移率(M.E.M.)检测恶性疾病。一项独立验证。
Lancet. 1972 Sep 23;2(7778):627-9. doi: 10.1016/s0140-6736(72)93018-8.
6
Specific lymphocyte sensitization in cancer: is there a common antigen in human malignant neoplasia?癌症中的特异性淋巴细胞致敏:人类恶性肿瘤中是否存在共同抗原?
Br Med J. 1971 Jun 12;2(5762):613-7. doi: 10.1136/bmj.2.5762.613.
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Lymphocyte sensitisation: an in-vitro test for cancer?淋巴细胞致敏:一种癌症的体外检测方法?
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Electrophoretic mobility test for lymphocyte sensitization using tanned sheep erythrocytes.使用鞣酸处理的绵羊红细胞进行淋巴细胞致敏的电泳迁移率试验。
Acta Biol Med Ger. 1975;34(4):K 29-32.
9
The use of the macrophage electrophoretic mobility test for the diagnosis of eye diseases.巨噬细胞电泳迁移率试验在眼病诊断中的应用。
Mod Probl Ophthalmol. 1976;16:259-64.
10
[Cellular immunity to donor antigens after kidney transplants in humans].[人类肾移植后对供体抗原的细胞免疫]
Z Exp Chir. 1975;8(6):350-5.