Guslandi M
Servizio di Gastroenterologia, Istituto Scientifico Ospedale San Raffaele, Milano.
Minerva Med. 1994 Apr;85(4):179-85.
Pinaverium bromide is a locally acting spasmolytic agent of the digestive tract. Its mechanism of action relies upon inhibition of calcium ion entrance into smooth muscle cells (calcium-antagonist effect). In humans pinaverium facilitates gastric emptying and decreases intestinal transit time in patients with constipation. Pinaverium is very effective in improving symptoms of irritable bowel syndrome (abdominal pain, gas, diarrhea or constipation). In this respect the drug proved to be significantly superior to placebo, at least as effective as trimebutine and on the whole more active than otilonium and prifinium bromide, being always extremely well tolerated.
溴丙胺太林是一种局部作用的消化道解痉剂。其作用机制依赖于抑制钙离子进入平滑肌细胞（钙拮抗作用）。在人体中，溴丙胺太林可促进胃排空，并缩短便秘患者的肠道传输时间。溴丙胺太林在改善肠易激综合征症状（腹痛、胀气、腹泻或便秘）方面非常有效。在这方面，该药物被证明明显优于安慰剂，至少与曲美布汀一样有效，总体上比奥替溴铵和丙胺太林更具活性，且耐受性一直非常好。
