tetA(B)基因中的突变会导致四环素外排泵的底物特异性发生变化。
Mutations in the tetA(B) gene that cause a change in substrate specificity of the tetracycline efflux pump.
作者信息
Guay G G, Tuckman M, Rothstein D M
机构信息
Department of Microbial Genetics, Lederle Laboratories, Pearl River, New York 10965.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):857-60. doi: 10.1128/AAC.38.4.857.
Abstract
The tetA(B) gene from transposon Tn10 fails to mediate resistance to the novel tetracycline analog 9-(dimethylglycylamido)minocycline (DMG-Mino) (P. E. Sum, V. J. Lee, R. T. Testa, J. J. Hlavka, G. A. Ellestad, J. D. Bloom, Y. Gluzman, and F. P. Tally, J. Med. Chem. 37:184-188, 1994; R. T. Testa, P. Petersen, N. V. Jacobus, P. E. Sum, V. J. Lee, and F. P. Tally, Antimicrob. Agents Chemother. 37:2270-2277, 1993). Mutations in either of two codons of tetA(B) that resulted in increased resistance to DMG-Mino also caused diminished resistance to tetracycline, identifying amino acid residues critical for the recognition of tetracycline.
摘要
转座子Tn10中的tetA(B)基因不能介导对新型四环素类似物9-(二甲基甘氨酰胺)米诺环素(DMG-米诺环素)的抗性(P. E. 萨姆、V. J. 李、R. T. 泰斯塔、J. J. 赫拉夫卡、G. A. 埃尔斯塔德、J. D. 布卢姆、Y. 格鲁兹曼和F. P. 塔利，《药物化学杂志》37:184 - 188, 1994；R. T. 泰斯塔、P. 彼得森、N. V. 雅各布斯、P. E. 萨姆、V. J. 李和F. P. 塔利，《抗菌药物与化疗》37:2270 - 2277, 1993)。tetA(B)两个密码子中的任何一个发生突变，导致对DMG-米诺环素的抗性增加，同时也导致对四环素的抗性降低，从而确定了对四环素识别至关重要的氨基酸残基。
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2
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3
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6
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