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Antimicrob Agents Chemother. 1994 Apr;38(4):865-7. doi: 10.1128/AAC.38.4.865.
2
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Chemotherapeutic effect of azithromycin and lasalocid on Cryptosporidium infection in mice.阿奇霉素和拉沙洛西对小鼠隐孢子虫感染的化疗作用。
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[Cryptosporidiosis in newborn calves in Ankara region: clinical, haematological findings and treatment with Lasalocid-NA].[安卡拉地区新生犊牛隐孢子虫病：临床、血液学表现及拉沙洛西钠治疗]
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Interdiscip Perspect Infect Dis. 2010;2010. doi: 10.1155/2010/753512. Epub 2010 Jul 14.
2
Reactive nitrogen and oxygen species ameliorate experimental cryptosporidiosis in the neonatal BALB/c mouse model.活性氮和氧物种改善新生BALB/c小鼠模型中的实验性隐孢子虫病。
Infect Immun. 1999 Nov;67(11):5885-91. doi: 10.1128/IAI.67.11.5885-5891.1999.
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Evaluation of maduramicin and alborixin in a SCID mouse model of chronic cryptosporidiosis.在慢性隐孢子虫病的SCID小鼠模型中对马杜霉素和阿博里辛的评估。
Antimicrob Agents Chemother. 1995 Apr;39(4):854-8. doi: 10.1128/AAC.39.4.854.
4
Arginine-derived nitric oxide reduces fecal oocyst shedding in nude mice infected with Cryptosporidium parvum.精氨酸衍生的一氧化氮可减少感染微小隐孢子虫的裸鼠粪便中卵囊的排出。
Infect Immun. 1994 Nov;62(11):5173-6. doi: 10.1128/iai.62.11.5173-5176.1994.

本文引用的文献

1
Effects of dehydroepiandrosterone in immunosuppressed rats infected with Cryptosporidium parvum.脱氢表雄酮对感染微小隐孢子虫的免疫抑制大鼠的影响。
J Parasitol. 1993 Jun;79(3):364-70.
2
Curative and preventive anticryptosporidium activities of sinefungin in an immunosuppressed adult rat model.西奈芬净在免疫抑制成年大鼠模型中的抗隐孢子虫治疗和预防活性
Antimicrob Agents Chemother. 1993 Apr;37(4):889-92. doi: 10.1128/AAC.37.4.889.
3
The natural history of cryptosporidial diarrhoea in HIV-infected patients.HIV感染患者隐孢子虫腹泻的自然病史。
AIDS. 1993 Mar;7(3):349-54. doi: 10.1097/00002030-199303000-00007.
4
Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model.在免疫抑制大鼠模型中评估候选抗隐孢子虫药物
J Infect Dis. 1993 Mar;167(3):766-8. doi: 10.1093/infdis/167.3.766.
5
Intensity of infection in AIDS-associated cryptosporidiosis.艾滋病相关隐孢子虫病的感染强度
J Infect Dis. 1993 Mar;167(3):704-9. doi: 10.1093/infdis/167.3.704.
6
Transplantability of human lymphoid cell line, lymphoma, and leukemia in splenectomized and/or irradiated nude mice.人淋巴细胞系、淋巴瘤和白血病在脾切除和/或照射的裸鼠中的移植性。
Cancer Res. 1980 Jul;40(7):2588-95.
7
Manipulation of the immune response in parasitic infections.寄生虫感染中免疫反应的调控
Parasitology. 1984 Aug;88 ( Pt 4):665-75. doi: 10.1017/s0031182000085589.
8
Treatment of intestinal cryptosporidiosis with spiramycin.用螺旋霉素治疗肠道隐孢子虫病。
Ann Intern Med. 1984 Aug;101(2):202-4. doi: 10.7326/0003-4819-101-2-202.
9
Isolation of Cryptosporidium oocysts and sporozoites using discontinuous sucrose and isopycnic Percoll gradients.使用不连续蔗糖和等密度 Percoll 梯度分离隐孢子虫卵囊和子孢子。
J Parasitol. 1987 Apr;73(2):314-9.
10
Cryptosporidiosis in perspective.隐孢子虫病概述。
Adv Parasitol. 1988;27:63-129. doi: 10.1016/s0065-308x(08)60353-x.

使用免疫缺陷小鼠模型测试的潜在抗隐孢子虫药物。

Putative anticryptosporidial agents tested with an immunodeficient mouse model.

作者信息

Leitch G J, He Q

机构信息

Department of Physiology, Morehouse School of Medicine, Atlanta, Georgia 30310.

出版信息

Antimicrob Agents Chemother. 1994 Apr;38(4):865-7. doi: 10.1128/AAC.38.4.865.

DOI:10.1128/AAC.38.4.865
PMID:8031061
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284557/
Abstract

Lasalocid, sinefungin, and dehydroepiandrosterone were tested for anticryptosporidial activity with an immunodeficient mouse model at doses that have been reported effective when tested with immunosuppressed rodent models. Small but significant reductions in oocyst excretion were only observed under some conditions with lasalocid and dehydroepiandrosterone, but sinefungin had no effect.

摘要

在免疫缺陷小鼠模型中，以在免疫抑制啮齿动物模型测试时已报道有效的剂量，对拉沙洛西钠、杀稻瘟菌素和脱氢表雄酮进行抗隐孢子虫活性测试。仅在某些条件下观察到拉沙洛西钠和脱氢表雄酮使卵囊排泄量有小幅但显著的减少，而杀稻瘟菌素则无效果。