177株对青霉素敏感及耐药的肺炎球菌对FK 037、头孢匹罗、头孢吡肟、头孢曲松、头孢噻肟、头孢他啶、亚胺培南、比阿培南、美罗培南及万古霉素的敏感性。
Susceptibilities of 177 penicillin-susceptible and -resistant pneumococci to FK 037, cefpirome, cefepime, ceftriaxone, cefotaxime, ceftazidime, imipenem, biapenem, meropenem, and vancomycin.
作者信息
Spangler S K, Jacobs M R, Appelbaum P C
机构信息
Department of Pathology (Clinical Microbiology), Hershey Medical Center, Pennsylvania 17033.
出版信息
Antimicrob Agents Chemother. 1994 Apr;38(4):898-900. doi: 10.1128/AAC.38.4.898.
Abstract
MICs of six extended-spectrum cephalosporins (cefotaxime, ceftriaxone, ceftazidime, FK 037, cefpirome, cefepime), three carbapenems (imipenem, meropenem, biapenem), and vancomycin for 49 penicillin-susceptible (S), 77 penicillin intermediate-resistant (I), and 51 penicillin-resistant (R) pneumococci were determined by agar dilution. Compared with ceftazidime (MICs for 90% of strains tested [MIC90s] of 2.0, 16.0, and 16.0 micrograms/ml for S, I, and R strains, respectively), all other cephalosporins yielded lower MICs (MIC90s of 0.06 to 0.125, 0.5 to 1.0, and 1.0 to 2.0 micrograms/ml against S, I, and R strains, respectively). All three carbapenems were very active, with MIC90s, even for R strains, of < or = 1.0 micrograms/ml. All strains were susceptible to vancomycin (MIC90 of 0.5 micrograms/ml).
摘要
采用琼脂稀释法测定了六种超广谱头孢菌素（头孢噻肟、头孢曲松、头孢他啶、FK 037、头孢匹罗、头孢吡肟）、三种碳青霉烯类抗生素（亚胺培南、美罗培南、比阿培南）和万古霉素对49株青霉素敏感（S）、77株青霉素中介耐药（I）和51株青霉素耐药（R）肺炎球菌的最低抑菌浓度（MIC）。与头孢他啶相比（S、I和R菌株的90%受试菌株的MIC[MIC90]分别为2.0、16.0和16.0微克/毫升），所有其他头孢菌素的MIC较低（对S、I和R菌株的MIC90分别为0.06至0.125、0.5至1.0和1.0至2.0微克/毫升）。所有三种碳青霉烯类抗生素都非常有效，即使对R菌株，MIC90也≤1.0微克/毫升。所有菌株对万古霉素敏感（MIC90为0.5微克/毫升）。
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本文引用的文献
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2
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Antimicrob Agents Chemother. 1984 Jun;25(6):710-8. doi: 10.1128/AAC.25.6.710.
3
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Antimicrob Agents Chemother. 1984 Aug;26(2):277-9. doi: 10.1128/AAC.26.2.277.
4
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J Antimicrob Chemother. 1983 Aug;12(2):133-9. doi: 10.1093/jac/12.2.133.
5
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6
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