耐青霉素肺炎链球菌对亚胺培南的敏感性降低。
Decreased susceptibility to imipenem among penicillin-resistant Streptococcus pneumoniae.
作者信息
Pikis A, Donkersloot J A, Akram S, Keith J M, Campos J M, Rodriguez W J
机构信息
Department of Infectious Diseases, Children's National Medical Center, Washington, DC 20010-2970, USA.
出版信息
J Antimicrob Chemother. 1997 Jul;40(1):105-8. doi: 10.1093/jac/40.1.105.
We assessed the antimicrobial susceptibilities of 59 penicillin-intermediate or penicillin-resistant pneumococci. All strains were susceptible to vancomycin and rifampicin. The frequency of strains with decreased susceptibility to cefotaxime, chloramphenicol, imipenem and meropenem was 15, 31, 47 and 49% respectively. The high percentage of penicillin-intermediate or penicillin-resistant Streptococcus pneumoniae with decreased susceptibility to third-generation cephalosporins, chloramphenicol and carbapenems limits the therapeutic options for the treatment of invasive pneumococcal infections and particularly of meningitis.
我们评估了59株青霉素中介或耐药肺炎球菌的抗菌药敏性。所有菌株对万古霉素和利福平敏感。对头孢噻肟、氯霉素、亚胺培南和美罗培南敏感性降低的菌株频率分别为15%、31%、47%和49%。对第三代头孢菌素、氯霉素和碳青霉烯类药物敏感性降低的青霉素中介或耐药肺炎链球菌比例较高，限制了侵袭性肺炎球菌感染尤其是脑膜炎的治疗选择。
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