荷兰带兔大脑小脑皮质大面积损伤后眨眼经典条件反射的重新获得

Reacquisition of eyeblink classical conditioning following large cerebellar cortical lesions in Dutch belted rabbits.

作者信息

Clark R E, Lavond D G

机构信息

Department of Psychology, University of Southern California, Los Angeles 90089-2520.

出版信息

Behav Brain Res. 1994 Mar 31;61(1):101-6. doi: 10.1016/0166-4328(94)90014-0.

DOI:10.1016/0166-4328(94)90014-0

PMID:8031490

Abstract

The effects of cerebellar lesions on a classically conditioned eyeblink response was examined using Dutch Belted rabbits as subjects. Results confirmed our previous findings, using New Zealand White rabbits, that cerebellar cortical lesions do not abolish conditioned responding if the interpositus is intact. However, unlike our previous studies using New Zealand White rabbits, Dutch Belted rabbits failed to reach a pre-lesion level of performance. These results suggest a possible important strain difference in this paradigm.

摘要

以荷兰带兔作为实验对象，研究了小脑损伤对经典条件反射性眨眼反应的影响。结果证实了我们之前以新西兰白兔为实验对象的研究结果，即如果间位核完整，小脑皮质损伤不会消除条件反应。然而，与我们之前使用新西兰白兔的研究不同，荷兰带兔未能恢复到损伤前的表现水平。这些结果表明在这个实验范式中可能存在重要的品系差异。