Brown R E, Ishak K G
Arch Pathol Lab Med. 1976 Mar;100(3):123-6.
Seven pediatric cases with hepatic peripheral zonal degeneration or necrosis in the liver, or both, were studied. From the standpoint of clinicopathological features, these cases fit best into the spectrum of Reye syndrome. Exogenous toxins, such as phosphorus and drugs, could not be implicated as principal causative factors in any of the cases. In the context of Reye syndrome, fatty acids would seem to have been the toxins most likely responsible for the pathogenesis of the peripheral zonal degeneration and necrosis in the liver.
对7例肝脏出现肝外周带变性或坏死或两者皆有的儿科病例进行了研究。从临床病理特征来看，这些病例最符合瑞氏综合征的范畴。在任何病例中，都不能将外源性毒素，如磷和药物，认定为主要致病因素。在瑞氏综合征的背景下，脂肪酸似乎是最有可能导致肝脏外周带变性和坏死发病机制的毒素。
