Fazakas-Todea I, Checiu M
Laboratory of Embryology and Teratology, Center of Medicine and for Sanitary Services and Management, Timişoara, Romania.
Rom J Morphol Embryol. 1996 Jan-Jun;42(1-2):33-40.
The effect of Indomethacin on beer-induced modifications of preimplantation development was investigated in rats (control on day 5 of pregnancy), using the following criteria: the mean number of embryos/animal, topographical distribution of embryos, the developmental stage attained, the appearance of pathological forms, the mean cell number/embryo. It resulted that previous administration of Indomethacin antagonized the main deleterious effect of repeated acute administration of beer in the preimplantation period, supporting the hypothesis of prostaglandins (PG) being involved in the pathogenetic action of this alcoholic beverage.
在大鼠（怀孕第5天的对照组）中研究了吲哚美辛对啤酒诱导的植入前发育改变的影响，采用以下标准：每只动物的平均胚胎数、胚胎的拓扑分布、达到的发育阶段、病理形式的出现、每个胚胎的平均细胞数。结果表明，预先给予吲哚美辛可拮抗在植入前期反复急性给予啤酒的主要有害作用，支持前列腺素（PG）参与这种酒精饮料致病作用的假说。
