Eden S, Cedar H
Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Curr Opin Genet Dev. 1994 Apr;4(2):255-9. doi: 10.1016/s0959-437x(05)80052-8.
DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.
DNA甲基化在发育过程中基因表达的调控中起着重要作用。CpG位点的甲基基团通过影响DNA与蛋白质的相互作用来抑制转录，从而改变细胞中基因对反式作用因子的可及性。由于这种机制是顺式作用的，所以在X染色体失活和基因组印记的控制中很重要。
