DNA甲基化在转录调控中的作用。
Role of DNA methylation in the regulation of transcription.
作者信息
Eden S, Cedar H
机构信息
Department of Cellular Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
出版信息
Curr Opin Genet Dev. 1994 Apr;4(2):255-9. doi: 10.1016/s0959-437x(05)80052-8.
PMID:8032203
Abstract
DNA methylation plays an important role in the regulation of gene expression during development. Methyl moieties at CpG residues suppress transcription by affecting DNA-protein interactions, thus altering the accessibility of genes to trans-acting factors in the cell. Because it works in cis, this mechanism is important in the control of X inactivation and genomic imprinting.
摘要
DNA甲基化在发育过程中基因表达的调控中起着重要作用。CpG位点的甲基基团通过影响DNA与蛋白质的相互作用来抑制转录，从而改变细胞中基因对反式作用因子的可及性。由于这种机制是顺式作用的，所以在X染色体失活和基因组印记的控制中很重要。
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