Niehrs C, Beisswanger R, Huttner W B
Institute for Neurobiology, University of Heidelberg, Germany.
Chem Biol Interact. 1994 Jun;92(1-3):257-71. doi: 10.1016/0009-2797(94)90068-x.
Sulfation is the most abundant post-translational modification of tyrosine residues and occurs in many soluble and membrane proteins passing through the secretory pathway of metazoan cells. The sulfation reaction is catalysed by tyrosylprotein sulfotransferase, a membrane-bound enzyme of the trans-Golgi-network. Tyrosylprotein sulfotransferase has been purified and its substrate specificity characterized. Tyrosine sulfation has been shown to be important for protein-protein interactions occurring during the intracellular transport of proteins and upon their secretion.
硫酸化是酪氨酸残基最丰富的翻译后修饰，发生在许多通过后生动物细胞分泌途径的可溶性和膜蛋白中。硫酸化反应由酪蛋白硫酸转移酶催化，该酶是反式高尔基体网络中的一种膜结合酶。酪蛋白硫酸转移酶已被纯化，其底物特异性也已得到表征。酪氨酸硫酸化已被证明对于蛋白质在细胞内运输和分泌过程中发生的蛋白质-蛋白质相互作用很重要。
