Agardh E, Agardh C D, Koul S, Torffvit O
Department of Ophthalmology, University Hospital, Lund, Sweden.
Diabet Med. 1994 Apr;11(3):273-8. doi: 10.1111/j.1464-5491.1994.tb00271.x.
Out of 369 diabetic patients with an age at onset of diabetes > or = 30 years previously studied, 325 (88%) were included in an ophthalmological follow-up examination 4 years later. In patients treated with oral drugs at baseline, the incidence of any type of retinopathy was 30.8% and of severe retinopathy 5.7%. All patients who developed severe retinopathy received insulin during the follow-up period. At baseline, duration of diabetes, diastolic blood pressure, and signs of nephropathy (p < 0.05 in all cases) as well as degree of metabolic control (p < 0.01) differed between patients who developed retinopathy and those who did not. At follow-up, there were no longer any differences regarding degree of metabolic control and diastolic blood pressure. In patients treated with insulin at baseline, the incidence of any type of retinopathy was 41.0% and of severe retinopathy 16.1%. At baseline, duration of diabetes (p < 0.01), degree of metabolic control, and insulin dosage (p < 0.05 in both cases) differed between patients who developed retinopathy and those who did not. At follow-up, there was no longer any difference in insulin dosage.
在之前研究的369例糖尿病发病年龄≥30岁的糖尿病患者中，4年后325例（88%）接受了眼科随访检查。基线时接受口服药物治疗的患者中，任何类型视网膜病变的发生率为30.8%，严重视网膜病变的发生率为5.7%。所有发生严重视网膜病变的患者在随访期间均接受了胰岛素治疗。基线时，发生视网膜病变的患者与未发生视网膜病变的患者在糖尿病病程、舒张压和肾病体征（所有情况p<0.05）以及代谢控制程度（p<0.01）方面存在差异。随访时，代谢控制程度和舒张压不再有差异。基线时接受胰岛素治疗的患者中，任何类型视网膜病变的发生率为41.0%，严重视网膜病变的发生率为16.1%。基线时，发生视网膜病变的患者与未发生视网膜病变的患者在糖尿病病程（p<0.01）、代谢控制程度和胰岛素剂量（两种情况p<0.05）方面存在差异。随访时，胰岛素剂量不再有差异。
