Hu J F, Liu Y Y, Yu Y K
Public Health College of Harbin Medical University.
Zhonghua Zhong Liu Za Zhi. 1994 Jan;16(1):18-21.
A case-control study with time-related factors was conducted to estimate the latency period of lung cancer. This study included 168 incident male cases of lung cancer histologically confirmed and 336 control patients with non-neoplastic diseases. All patients were interviewed in the hospital wards from May 1987 to May 1990. Data concerning smoking, occupation, method of house heating and cooking fuel used from twelve time windows of looking forward and diet were obtained for three periods of time. A synthetical analysis of forward measures and backward measures were applied. By means of calculating accumulated effective exposure score and excess exposure fraction, the latency period of lung cancer was estimated using multivariate model. Latency of lung cancer is 54.48 years for indoor air pollution, and 56.17 years for total smoking. From estimating latency period of lung cancer from multivariate analysis, it was found that the latency of lung cancer could be affected by the effects of other factors. Therefore, measures which prolong latency period may be of use in the prevention of lung cancer.
开展了一项包含时间相关因素的病例对照研究，以估算肺癌的潜伏期。该研究纳入了168例经组织学确诊的男性肺癌新发病例以及336例患有非肿瘤性疾病的对照患者。1987年5月至1990年5月期间，所有患者均在医院病房接受了访谈。针对三个时间段，从十二个前瞻时间窗获取了有关吸烟、职业、房屋取暖方式以及饮食所用烹饪燃料的数据。应用了前瞻性测量和回顾性测量的综合分析方法。通过计算累积有效暴露得分和超额暴露分数，使用多变量模型估算肺癌的潜伏期。室内空气污染导致肺癌的潜伏期为54.48年，吸烟总量导致肺癌的潜伏期为56.17年。从多变量分析估算肺癌潜伏期发现，肺癌潜伏期可能受其他因素影响。因此，延长潜伏期的措施可能对预防肺癌有用。
