孕中期羊水中胎盘碱性磷酸酶水平在唐氏综合征中较低，但在其他胎儿异常中并非如此。

Second trimester amniotic fluid placental alkaline phosphatase levels are low in Down's syndrome but not in other fetal abnormalities.

作者信息

Ind T E, Iles R K, Wathen N C, Carvalho C, Campbell J, Chard T

机构信息

Department of Reproductive Physiology, St Bartholomew's Hospital, West Smithfield, London, UK.

出版信息

Early Hum Dev. 1994 Apr 30;37(1):39-44. doi: 10.1016/0378-3782(94)90145-7.

DOI:10.1016/0378-3782(94)90145-7

PMID:8033786

Abstract

Second trimester amniotic fluid placental alkaline phosphatase (PLAP) immunoreactivity was measured in 756 normal pregnancies, 63 Down's syndrome pregnancies and 42 pregnancies associated with other chromosomal abnormalities. PLAP levels were significantly reduced in cases of Down's syndrome (MoM = 0.72, U = 17,565, P = 0.0002, 95% Cl = 0.63-0.88). However, there was no significant difference between other aneuploid conditions and the normals (MoM = 0.88, U = 13,289, P = 0.35, 95% CI = 0.77-1.08). PLAP is the carrier protein for immunoglobulin G. Neonates with Downs syndrome but not other chromosomal abnormalities are associated with a deficiency of IgG. These data therefore support the theory that the low IgG levels in Downs syndrome are a result of a defect in PLAP transport.

摘要

在756例正常妊娠、63例唐氏综合征妊娠和42例伴有其他染色体异常的妊娠中，检测了孕中期羊水胎盘碱性磷酸酶（PLAP）的免疫反应性。唐氏综合征病例的PLAP水平显著降低（中位数倍数MoM = 0.72，U = 17565，P = 0.0002，95%可信区间Cl = 0.63 - 0.88）。然而，其他非整倍体情况与正常情况之间没有显著差异（MoM = 0.88，U = 13289，P = 0.35，95%可信区间CI = 0.77 - 1.08）。PLAP是免疫球蛋白G的载体蛋白。患有唐氏综合征而非其他染色体异常的新生儿与IgG缺乏有关。因此，这些数据支持了唐氏综合征中低IgG水平是PLAP转运缺陷所致的理论。